Chemical Properties
White solid
Uses
(Phenylthio)acetic acid is a reactant in the preparation of benzoxazoles, benzimidazoles, and benzothiazoles, which exhibit antimicrobial activity.
Application
(Phenylthio)acetic Acid (PTAA) is used for preparation of various PhS-containing compounds, such as 3- or 4-hydroxy-2-(phenylthio)alkanoic acids, 4-oxo-2-(phenylthio)alkanoic acids, and α-phenylthio-β-lactams.
Preparation
(Phenylthio)acetic acid is prepared by the substitution reaction of sodium chloroacetate with sodium benzenethiolate, or
by the treatment of bromoacetic acid with thallium(I) benzenethiolate.
[1]
References
1. Detty, M. R.; Wood, G. P. JOC 1980, 45, 80.