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N-Hydroxyphthalimide

N-Hydroxyphthalimide Structure
N-Hydroxyphthalimide
  • CAS No.524-38-9
  • Chemical Name:N-Hydroxyphthalimide
  • CBNumber:CB2332640
  • Molecular Formula:C8H5NO3
  • Formula Weight:163.13
  • MOL File:524-38-9.mol
N-Hydroxyphthalimide Property
  • Melting point: :233 °C (dec.) (lit.)
  • Boiling point: :290.19°C (rough estimate)
  • Density  :1.64 g/cm3
  • refractive index  :1.5510 (estimate)
  • storage temp.  :Keep in dark place,Sealed in dry,Room Temperature
  • pka :6.10±0.20(Predicted)
  • form  :Powder
  • color  :Yellow
  • Water Solubility  :Slightly soluble in water.
  • Merck  :14,4838
  • BRN  :131208
  • InChIKey :CFMZSMGAMPBRBE-UHFFFAOYSA-N
  • CAS DataBase Reference :524-38-9(CAS DataBase Reference)
  • FDA UNII :BXI99M81X0
  • EPA Substance Registry System :1H-Isoindole-1,3(2H)-dione, 2-hydroxy- (524-38-9)
Safety
  • Hazard Codes  :Xi
  • Risk Statements  :36/37/38
  • Safety Statements  :26-36-37/39
  • WGK Germany  :3
  • RTECS  :TI5200000
  • TSCA  :Yes
  • HazardClass  :IRRITANT
  • HS Code  :29251995
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H335-H315-H319
  • Precautionary statements P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P305+P351+P338-P405-P501a
N-Hydroxyphthalimide Price More Price(9)
  • Brand: Sigma-Aldrich
  • Product number: H53704
  • Product name : N-Hydroxyphthalimide
  • Purity: 97%
  • Packaging: 100g
  • Price: $38.7
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: H53704
  • Product name : N-Hydroxyphthalimide
  • Purity: 97%
  • Packaging: 5g
  • Price: $17.6
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: TCI Chemical
  • Product number: H0395
  • Product name : N-Hydroxyphthalimide
  • Purity: >99.0%(T)
  • Packaging: 25g
  • Price: $17
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: TCI Chemical
  • Product number: H0395
  • Product name : N-Hydroxyphthalimide
  • Purity: >99.0%(T)
  • Packaging: 100g
  • Price: $48
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Alfa Aesar
  • Product number: A13862
  • Product name : N-Hydroxyphthalimide, 98+%
  • Purity: 
  • Packaging: 500g
  • Price: $126
  • Updated: 2021/03/22
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N-Hydroxyphthalimide Chemical Properties,Usage,Production

  • Chemical Properties N-Hydroxyphthalimide is yellow moist powder
  • Uses N-Hydroxyphthalimide,additives in to DCC method of peptide synthesis used to improve yield of optically pure product.
  • Uses Catalyst for oxidation reactions.
  • Synthesis Reference(s) Tetrahedron Letters, 37, p. 2035, 1996 DOI: 10.1016/0040-4039(96)00211-0
  • Purification Methods N -Hydroxyphthalimide [524-38-9] M 163.1, m 230o, ~235o(dec), 237-240o, 7.0. Dissolve the imide in H2O by adding Et3N to form the salt and while hot, acidify, cool and pour into a large volume of H2O. Filter off the solid, wash it with H2O and dry it over P2O5 in a vacuum. [Nefken & Teser J Am Chem Soc 83 1263 1961, Fieser 1 485 1976, Nefkens et al. Recl Trav Chim, Pays-Bas 81 683 1962] The O-acetyl derivative has m 178-180o (from EtOH). [Beilstein 21/11 V 100.]
N-Hydroxyphthalimide Preparation Products And Raw materials
Raw materials
Preparation Products
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524-38-9, N-HydroxyphthalimideRelated Search:
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  • N-Hydroxyphthalimide, 98%, for synthesis
  • Droxidopa Impurity 14
  • N-Hydroxyphthalimide USP/EP/BP
  • 524-38-9
  • Carbon Radical Producing Catalysts (Environmentally-friendly Oxidation)
  • Peptide Synthesis
  • Condensation & Active Esterification
  • Coupling Reactions (Peptide Synthesis)
  • Coupling
  • Synthetic Reagents
  • Environmentally-friendly Oxidation
  • N-Substituted Maleimides, Succinimides & Phthalimides
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  • Active Esters/Additives
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