WAY-151932

WAY-151932 (VNA-932) stimulates cAMP formation in LV2 cells expressing the hV ₂ receptors in a dose-dependent manner with an EC ₅₀ of 0.74±0.07 nM.

Oral administration of WAY-151932 (VNA-932) to water-loaded conscious rats produces a dose-dependent decrease in urine volume (ED ₅₀ =0.14 mg/kg, 2.5% starch in water vehicle) and a corresponding increase in osmolality without altering the urine electrolyte excretion profile.

IC50: 80.3 nM (human-V2 binding), 778 nM (human-V1a binding)