220460-92-4

Name	WAY-151932
CAS	220460-92-4
Molecular Formula	C23H19ClN4O
MDL Number	MFCD05662330
Molecular Weight	402.88
MOL File	220460-92-4.mol

Synonyms

VNA-932 WAY-151932 Methanone, [2-chloro-4-(3-methyl-1H-pyrazol-1-yl)phenyl]-5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-yl-

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Chemical Properties

Boiling point	630.6±55.0 °C(Predicted)
density	1.33±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	Soluble in DMSO
form	Solid
pka	0.04±0.12(Predicted)
color	White to off-white

Hazard Information

Uses

WAY-151932 is a vasopressin V2-receptor agonist with IC50 of 80.3 nM and 778 nM in human-V2 binding and V1a binding assay.

Biological Activity

WAY-151932 is an antidiuretic hormone V2 receptor agonist with IC50 of 80.3 and 778 nM in human V2 and V1a binding assays, respectively.

in vitro

WAY-151932 (VNA-932) stimulates cAMP formation in LV2 cells expressing the hV ₂ receptors in a dose-dependent manner with an EC ₅₀ of 0.74±0.07 nM.

in vivo

Oral administration of WAY-151932 (VNA-932) to water-loaded conscious rats produces a dose-dependent decrease in urine volume (ED ₅₀ =0.14 mg/kg, 2.5% starch in water vehicle) and a corresponding increase in osmolality without altering the urine electrolyte excretion profile.

target

IC50: 80.3 nM (human-V2 binding), 778 nM (human-V1a binding)

storage

Store at -20°C

References

[1] Molinari AJ, et al. Identification and synthesis of major metabolites of Vasopressin V2-receptor agonist WAY-151932, and antagonist, Lixivaptan. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5796-800. DOI:10.1016/j.bmcl.2007.08.053
[2] Failli AA, et al. Pyridobenzodiazepines: a novel class of orally active, vasopressin V2 receptor selective agonists. Bioorg Med Chem Lett. 2006 Feb 15;16(4):954-9. DOI:10.1016/j.bmcl.2005.10.107

Supplier

Shanghai Amico Chemicals Co. LTD

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TargetMol Chemicals Inc.

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Websitehttps://www.targetmol.cn/

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