WAY-151932

Product NameWAY-151932
CAS220460-92-4
MFC23H19ClN4O
MW402.88
EINECS
MOL File220460-92-4.mol

Chemical Properties

Boiling point	630.6±55.0 °C(Predicted)
Density	1.33±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	Soluble in DMSO
form	Solid
pka	0.04±0.12(Predicted)
color	White to off-white

Usage And Synthesis

Biological Activity

WAY-151932 is an antidiuretic hormone V2 receptor agonist with IC50 of 80.3 and 778 nM in human V2 and V1a binding assays, respectively.

in vitro

WAY-151932 (VNA-932) stimulates cAMP formation in LV2 cells expressing the hV ₂ receptors in a dose-dependent manner with an EC ₅₀ of 0.74±0.07 nM.

in vivo

Oral administration of WAY-151932 (VNA-932) to water-loaded conscious rats produces a dose-dependent decrease in urine volume (ED ₅₀ =0.14 mg/kg, 2.5% starch in water vehicle) and a corresponding increase in osmolality without altering the urine electrolyte excretion profile.

target

IC50: 80.3 nM (human-V2 binding), 778 nM (human-V1a binding)