Uses
Adenylosuccinic acid (Adenylosuccinate; Aspartyl adenylate) is a purine ribonucleoside monophosphate and plays a role in nucleotide cycle metabolite. Adenylosuccinic acid can be converted into fumaric acid through adenylosuccinate lyase. Adenylosuccinic acid has the potential for the study of duchenne muscular dystrophy(DMD)[1].
References
[1] Timpani CA, et al. Adenylosuccinic acid therapy ameliorates murine Duchenne Muscular Dystrophy.Sci Rep. 2020 Jan 24;10(1):1125. DOI:
10.1038/s41598-020-57610-w[2] WAARDE A V. OPERATION OF THE PURINE NUCLEOTIDE CYCLE IN ANIMAL TISSUES[J]. Biological Reviews, 1988, 63 2: 259-298. DOI:
10.1111/j.1469-185x.1988.tb00632.x[3] HALONEN J, NEDERGAARD J. Adenosine 5-Monophosphate Is a Selective Inhibitor of the Brown Adipocyte Nonselective Cation Channel[J]. The Journal of Membrane Biology, 2002, 14 1: 0. DOI:
10.1007/s00232-001-0184-0[4] Y. NISHIDA T. M. Contractile effect of succinylpurines on guinea pig uterus[J]. General Pharmacology-the Vascular System, 1988, 19 2: Pages 277-279. DOI:
10.1016/0306-3623(88)90076-6[5] JESSICA R GOODING. Adenylosuccinate Is an Insulin Secretagogue Derived from Glucose-Induced Purine Metabolism.[J]. Cell reports, 2015, 13 1: 157-167. DOI:
10.1016/j.celrep.2015.08.072[6] TARAKA R. DONTI . Diagnosis of adenylosuccinate lyase deficiency by metabolomic profiling in plasma reveals a phenotypic spectrum[J]. Molecular Genetics and Metabolism Reports, 2016, 8: Pages 61-66. DOI:
10.1016/j.ymgmr.2016.07.007
