Description
Cholesteryl oleate is a cholesterol ester. It has been used in the generation of nanoparticles and liposomes for drug delivery.
Chemical Properties
white to off-white powder, lumpy powder or pale
Uses
Cholesteryl oleate was used to study the ability of silicone hydrogel contact lenses to absorb tear lipids, cholesterol and cholesterol esters. It was also used in the development of amperometric cholesterol biosensors.
Definition
ChEBI: The (Z)-stereoisomer of cholesteryl octadec-9-enoate.
Biochem/physiol Actions
Cholesterol in plasma is present in an esterified form such as Cholesteryl oleate. The liver is a primary source of cholesteryl oleate that enriches the LDL particles when released into plasma. The secretion of lipoproteins enriched with cholesteryl oleate has close correlation with the pathogenesis of coronary artery atherosclerosis.
Purification Methods
Purify the oleate ester by chromatography on silica gel and eluting with MeOH. [Beilstein 6 III 2642.]
