Description
CID797718 is a protein kinase D1 (PKD1) inhibitor (IC
50 = 7 μM). It also inhibits CDK activating kinase (CAK) and polo-like kinase 1 (PLK1) but has no activity at AKT (IC
50s = 8.4, 21.9, and >50 μM, respectively). CID797718 inhibits PKD1 activity in LNCaP cells with an IC
50 value of 0.21 μM. CID797718 is a byproduct in the synthesis of CID755673 .
References
[1] ELIZABETH R SHARLOW. Potent and selective disruption of protein kinase D functionality by a benzoxoloazepinolone.[J]. The Journal of Biological Chemistry, 2008, 283 48: 33516-33526. DOI:
10.1074/jbc.m805358200[2] COURTNEY R LAVALLE. Novel protein kinase D inhibitors cause potent arrest in prostate cancer cell growth and motility.[J]. BMC chemical biology, 2010, 10: 5. DOI:
10.1186/1472-6769-10-5
