Description
Kinsenoside is a glycoside originally isolated from
A. formosanus that has diverse biological activities, including antihyperlipidemic, immunosuppressive, and anti-inflammatory properties. It increases lipolysis mediated by adipose triglyceride lipase and increases hydrolysis of triglycerides in C3H10T1/2 adipocytes. It also increases phosphorylation of peroxisome proliferator-activated receptor α (PPARα) and CREB as well as protein levels of SIRT1, PGC-1α, and carnitine palmitoyltransferase I. Kinsenoside downregulates the expression and phosphorylation of VEGF receptor 2 (VEGFR2) and inhibits crosstalk between the JAK2/STAT3 and PI3K/AKT signaling pathways in dendritic cells
in vitro. It decreases the production of IFN-γ, IL-17, and TNF-α and increases the production of IL-10 in splenocytes isolated from mice with collagen-induced arthritis (CIA). Kinsenoside (300 mg/kg per day) decreases the expression of IL-1β, TNF-α, and matrix metalloproteinase-9 (MMP-9) and increases the expression of IL-10 in inflamed joints in a mouse model of collagen-induced arthritis and prevents paw edema and reduces the severity of arthritis.
Uses
Kinsenoside is an anti-hyperlipidemic agent isolated from the plant Anoect chilus.
Definition
ChEBI: (3R)-5-Oxotetrahydro-3-furanyl beta-D-glucopyranoside is a glycoside.
in vivo
Kinsenoside (10 mg/kg; ip; every 3 days for 4 weeks) promotes the expression of Nrf2 and ameliorates intervertebral disc degeneration (IDD) induced by Pentobarbital (50 mg/kg) in vivo in rat model[1].
Kinsenoside (100 mg/kg, 300 mg/kg; ip; 1 h before LPS induction) inhibits LPS (40 mg/kg; ip)-induced inflammatory model in mice[3].
References
[1] X M DU. Glycosidic constituents from in vitro Anoectochilus formosanus.[J]. Chemical & pharmaceutical bulletin, 2000, 48 11: 1803-1804. DOI:
10.1248/cpb.48.1803[2] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[3] HUNG-BO HSIAO. Kinsenoside inhibits the inflammatory mediator release in a type-II collagen induced arthritis mouse model by regulating the T cells responses[J]. BMC Complementary and Alternative Medicine, 2016, 16 1. DOI:
10.1186/s12906-016-1054-8[4] MING XIANG. Effects of kinsenoside, a potential immunosuppressive drug for autoimmune hepatitis, on dendritic cells/CD8+T cells communication in mice[J]. Hepatology, 2016, 64 6: 2135-2150. DOI:
10.1002/hep.28825
