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Bisacodyl

Bisacodyl Structure
Bisacodyl
  • CAS No.603-50-9
  • Chemical Name:Bisacodyl
  • CBNumber:CB2233693
  • Molecular Formula:C22H19NO4
  • Formula Weight:361.39
  • MOL File:603-50-9.mol
Bisacodyl Property
  • Melting point: :138°C
  • Boiling point: :493.21°C (rough estimate)
  • Density  :1.2545 (rough estimate)
  • refractive index  :1.5614 (estimate)
  • storage temp.  :Sealed in dry,2-8°C
  • solubility  :Practically insoluble in water, soluble in acetone, sparingly soluble in ethanol (96 per cent). It dissolves in dilute mineral acids.
  • form  :neat
  • pka :4.69±0.10(Predicted)
  • Water Solubility  :Soluble in alcohol (slightly), ether (slightly), chloroform, and acetone. Insoluble in water.
  • λmax :220nm(MeOH)(lit.)
  • Merck  :14,1242
  • Stability: :Stable. Incompatible with strong oxidizing agents.
  • InChIKey :KHOITXIGCFIULA-UHFFFAOYSA-N
  • CAS DataBase Reference :603-50-9(CAS DataBase Reference)
  • EWG's Food Scores :1
  • FDA UNII :10X0709Y6I
  • NCI Drug Dictionary :bisacodyl
  • NIST Chemistry Reference :Bisacodyl(603-50-9)
  • EPA Substance Registry System :Phenol, 4,4'-(2-pyridinylmethylene)bis-, diacetate (ester) (603-50-9)
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H315-H319-H335
  • Precautionary statements P305+P351+P338-P261
Bisacodyl Price More Price(14)
  • Brand: Sigma-Aldrich
  • Product number: B1390
  • Product name : Bisacodyl
  • Purity: analytical standard, for drug analysis
  • Packaging: 10g
  • Price: $79.9
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: B1140000
  • Product name : Bisacodyl
  • Purity: European Pharmacopoeia (EP) Reference Standard
  • Packaging: b1140000
  • Price: $190
  • Updated: 2020/08/18
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: B1140000
  • Product name : Bisacodyl
  • Purity: European Pharmacopoeia (EP) Reference Standard
  • Packaging: 
  • Price: $190
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: TCI Chemical
  • Product number: B5066
  • Product name : Bisacodyl
  • Purity: >98.0%(HPLC)(T)
  • Packaging: 5g
  • Price: $71
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: TCI Chemical
  • Product number: B5066
  • Product name : Bisacodyl
  • Purity: >98.0%(HPLC)(T)
  • Packaging: 25g
  • Price: $222
  • Updated: 2021/03/22
  • Buy: Buy

Bisacodyl Chemical Properties,Usage,Production

  • Chemical Properties Crystalline Solid
  • Originator Dulcolax,Boehringer Ingelheim,US,1958
  • Uses Cathartic.
  • Uses Stimulant laxative.
  • Manufacturing Process Preparation of (4,4'-Dihydroxy-Diphenyl)-(Pyridyl-2)-Methane 70.0 grams of α-pyridine aldehyde are fed portionwise with stirring and cooling to a mixture of 200 grams of phenol and 100 cc of concentrated sulfuric acid. The reaction mixture is allowed to stand for a while with repeated stirring, whereby it becomes syrupy, neutralized with sodium carbonate, dissolved in methanol and filtered. The filtrate is introduced into a large quantity of water and the resulting precipitate is recrystallized from a methanol/water mixture. Colorless crystals are obtained of MP 254°C. When using zinc chloride or tin tetrachloride and warming to a temperature of about 50°C, a corresponding result is obtained.
    Preparation of Bisacodyl: 5 grams of (4,4'-dihydroxy-diphenyl)-(pyridyl-2)- methane are heated with 5 grams of anhydrous sodium acetate and 20 cc of acetic anhydride for three hours over a boiling water bath. The cooled reaction mixture is poured into water, whereby after a while a colorless substance precipitates, which is filtered off with suction, washed with water and recrystallized from aqueous ethanol. Colorless bright crystals, MP 138°C are obtained.
  • brand name Correctol Tablets, Caplets (Schering-Plough HealthCare); Dulcolax (Boehringer Ingelheim); Evac-Q-Tabs (Savage); Feen-a- Mint Tablets (Schering-Plough HealthCare); Modane (Savage); SK-Bisacodyl (SmithKline Beecham); Theralax (SmithKline Beecham).
  • Therapeutic Function Laxative
  • Veterinary Drugs and Treatments Bisacodyl oral and rectal products are used as stimulant cathartics in dogs and cats.
Bisacodyl Preparation Products And Raw materials
Raw materials
Preparation Products
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603-50-9, BisacodylRelated Search:
  • 2-(4,4’-diacetoxydiphenylmethyl)pyridine
  • 2-(4,4'-Diacetoxydiphenylmethyl)pyridine
  • 4,4'-(2-Pyridylmethylene)diphenol diacetate
  • 4,4'-(2-Pyridylmethylene)diphenol diacetate (ester)
  • 4,4’-(2-pyridinylmethylene)bis-phenodiacetate(ester)
  • 4,4’-(2-pyridylmethylene)di-phenodiacetate(ester)
  • 4,4’-(2-pyridylmethylene)-diphenolacetate
  • 4,4’-(2-Pyridylmethylene)-diphenolace-tate
  • 4,4’-(2-pyridylmethylene)diphenoldiacetate
  • neolax
  • nigalax
  • Phenol, 4,4'-(2-pyridinylmethylene)bis-, diacetate
  • Phenol, 4,4'-(2-pyridinylmethylene)bis-, diacetate (ester)
  • Phenol, 4,4'-(2-pyridylmethylene)di-, diacetate
  • phenol,4,4’-(2-pyridinylmethylene)bis-,diacetate(ester)
  • Pyrilax
  • sanvacual
  • Sk-bisacodyl
  • stadalax
  • telemin
  • Theralax
  • BISACODYL
  • AURORA KA-6302
  • GENTLAX (PURDUE FREDERICK)
  • EX-LAX ULTRA (NOVARTIS)
  • LAXADIN (TEVA)
  • LABOTEST-BB LT00134695
  • DULCOLAN (BOEHRINGER, ING)
  • dulcolax
  • DULCOLAX (BOEHRINGER, ING)
  • DUROLAX (BOEHRINGER, ING)
  • CONTALAX (3M PHARMA)
  • CORRECTOL (SCHERING-PLOUGH)
  • STADALAX (STADA)
  • PERILAX (FERRING)
  • PYRILAX (BERLIN-CHEMIE)
  • 4,4'-DIACETOXYDIPHENYLPYRIDYL-2-METHANE
  • [4-[(4-acetyloxyphenyl)-pyridin-2-ylmethyl]phenyl] acetate
  • 4,4'-(2-pyridylmethylene)bisphenol diacetate
  • (4,4’-diacetoxydiphenyl)(2-pyridyl)methane
  • (4,4'-Diacetoxydiphenyl)(2-pyridyl)methane
  • 4,4’-diacetoxydiphenylpyrid-2-ylmethane
  • 4,4'-Diacetoxydiphenylpyrid-2-ylmethane
  • 4-[[4-(Acetyloxy)phenyl](2-pyridinyl)methyl]phenyl acetate
  • Bicol
  • bicosacodyl
  • Bis(p-acetoxyphenyl)-2-pyridylmethane
  • brocalax
  • broxalax
  • deficol
  • Di-(4-acetoxyphenyl)-2-pyridylmethane
  • Di-(p-acetoxyphenyl)-2-pyridylmethane
  • Dulcolan
  • durolax
  • endokolat
  • eulaxan
  • fenilaxan
  • godalax