BW-180C ( [D-Ala2, D-Leu5]-Enkephalin; DADLE) protects liver against ischemia-reperfusion injury in the rat. DADLE (5 mg/kg) protects the heart, lung, and jejunum against ischemia-reperfusion (I-R) injury[2].
BW-180C (DADLE) improves hepatic ischemia/reperfusion injury in mice via activation of the Nrf2/HO1 pathway[3].
DADLE (5 mg/kg) significantly reduces the levels of alanine aminotransferase and aspartate aminotransferase in the serum, and the levels of malondialdehyde in the liver homogenate[3].
| Animal Model: | Male Wistar rats weighing 200 to 250 g[2] |
| Dosage: | 5 mg/kg
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| Administration: | Administered intravenously into the inferior vena cava
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| Result: | After 120 min of reperfusion, the serum GPT levels were significantly lower in the DADLE group than in the Control group.
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| Animal Model: | Male C57BL/6 mice (age, 35-42 days; weight, 18-22 g; 6 mice in each group)[3] |
| Dosage: | 5 mg/kg
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| Administration: | Injected intraperitoneally 15 min prior to I/R
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| Result: | The serum levels of AST and ALT in the serum DADLE group were significantly lower.
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