2-Benzylamino-2-methyl-1-propanol

Uses

2-Benzylamino-2-methyl-1-propanol, as a basic skeleton, is commonly used as an organic ligand in the structural modification and synthesis of oxazoline ligands. These ligands have wide applications in coordination chemistry and organometallic chemistry, playing a particularly important role in catalytic reactions. As a fundamental skeleton in organic synthesis, this molecule is frequently used in basic organic chemistry research to explore new reaction pathways, catalyst design, and synthetic methods for novel organic ligands.

Chemical Properties

Yellow-Orange Solid

Synthesis Reference(s)

Tetrahedron, 44, p. 6801, 1988 DOI: 10.1016/S0040-4020(01)86206-2

Synthesis

To a solution of 2-amino-2-methylpropan-1-ol (1 g, 11.22 mmol) and benzaldehyde (1.310 g, 12.34 mmol) in DCE (15 mL) at RT was added portionwise sodium triacetoxyborohydride (6.66 g, 31.4 mmol), and the mixture was stirred for 3 h. The mixture was diluted with EtOAc and washed with saturated aqueous NaHCO3. The organic layer was dried over MgSO4, filtered, and concentrated. The crude product 2-Benzylamino-2-methyl-1-propanol (1.247 g, 6.96 mmol, 62 % yield) was used without further purification. LCMS (m/z): 180.0 (M+H+).