Manufacturing Process
3-Chloro-4',6'-dimethyl-o-propananisidide was prepared by using 92.8 g
(0.615 mol) 4,6-dimethyl-o-anisidine and 86 g (0.68 mol) of 3-chloropropionyl
chloride, melting point 123-125°C. A mixture containing 40 g (0.165 mol) of
3-chloro-4',6'-dimethyl-o-propananisidide, 54.3 g of 3-methyl piperidine, and
330 ml of anhydrous benzene was heated for 72 hours at 65°C. 47.7 g (84.5%) of N-(2-methoxy-4,6-dimethylphenyl)-2-methyl-1-
piperidinepropanamide hydrochloride was obtained by deposition of product in
anhydrous acetone saturated with hydrogen chloride; melting point 192-193°C
(crystallization from a mixture isopropanol-acetone).
