Description
1-Deoxynojirimycin (1-DNJ) is an iminosugar that has been found in
M. alba (mulberry) leaves and has diverse biological activities. It inhibits the activities of α- and β-glucosidase (IC
50s = 35 and 71 μM, respectively). 1-DNJ (5 mM) reduces the formation of N-linked complex oligosaccharides in IEC-6 cells. It inhibits HIV-1 envelope-mediated membrane fusion in CEM cells when used at a concentration of 2 mM. 1-DNJ (1-100 μg/ml) reduces the invasion and migration of B16/F10 mouse melanoma cells. It improves glucose and insulin tolerance in
db/db mice when administered intravenously at doses ranging from 20 to 80 mg/kg per day for four weeks.
General Description
Specific glucosidase inhibitor, including trimming glucosidases I and II, that sequentially removes the three glucose residues from precursor Glc
3Man
9GlcNAc
2 in N-linked glycan biosynthesis.
