Chemical Properties
Acute toxicity LD50 mice (mmol/kg): 14 IV. Gadodiamide for injection: C16H28GdN5O9C16H26CaN5NaO8.[131410-51-0]. Viscosity (Pas): 0.002 (20°C), 0.0014 (37°C). d20 1.13. partition coefficient (butanol/water): -2.1. acute toxicity LD50 mice (mmol/kg): 34 IV.
Uses
efers to the substance containing the water of coordination and multiple (x) waters of hydration.
Uses
Gadodiamide is an apoptosis inducing agent used in chondrocytes. It is primarily used in muscoskeletal diagnosis as a contrast agent.
Definition
ChEBI: A non-ionic gadolinium chelate having a macrocyclic triamine framework. It is used as a paramagnetic contrast agent in magnetic resonance imaging (MRI).
General Description
Gadodiamide is a clear,colorless to slightly yellow, gadolinium-based contrastagent indicated to visualize lesions with abnormal vascularityin the CNS and body. It is a nonionic gadoliniumcomplex administered by intravenous injection with an osmolalityof 2.8 times that of plasma. Gadodiamide decreasesboth the T1 and T2 relaxation times in tissueswhere it is distributed. In clinical MRI, the effect is primarily on the T1 relaxation time resulting in an increase inT1-weighted sequence signal intensity.
