ChemicalBook CAS DataBase List (E)-3-[[[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-[[(3-dimethylamino)-3-oxopropyl]thio]methyl]thio]-propanoic acid, sodium salt

(E)-3-[[[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-[[(3-dimethylamino)-3-oxopropyl]thio]methyl]thio]-propanoic acid, sodium salt

Product Name(E)-3-[[[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-[[(3-dimethylamino)-3-oxopropyl]thio]methyl]thio]-propanoic acid, sodium salt
CAS115104-28-4
CBNumberCB1491027
MFC26H27ClN2O3S2
MW515.09
MDL NumberMFCD00797675
MOL File115104-28-4.mol
MSDS FileSDS

Chemical Properties

Melting point	65-70°C
Boiling point	712.3±60.0 °C(Predicted)
Density	1.327±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	Soluble in DMSO (up to 50 mg/ml).
pka	4.27±0.10(Predicted)
form	Off-white solid.
color	Yellow
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
InChIKey	AXUZQJFHDNNPFG-UXBLZVDNSA-N
SMILES	S(C(SCCC(=O)O)c1cc(ccc1)\C=C\c2nc3c(cc2)ccc(c3)Cl)CCC(=O)N(C)C
FDA UNII	76LB1G2X6V
UNSPSC Code	12352211
NACRES	NA.77

Safety

Symbol(GHS)

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501

WGK Germany

WGK 1

Storage Class

11 - Combustible Solids

NFPA 704:

	0
2		0

(E)-3-[[[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-[[(3-dimethylamino)-3-oxopropyl]thio]methyl]thio]-propanoic acid, sodium salt Price

Product number	Packaging	Price	Product description	Buy
Sigma-Aldrich 475874-M	5 mg	$163	MK571, Sodium Salt A selective, competitive antagonist of leukotriene D4</sub> (LTD4</sub>) (K<sub>i</sub> = 2.1 nM for inhibition of [³H]LTD4</sub> binding to human lung membranes).	Buy
Sigma-Aldrich 475874-M	1 unit	$152	MK571, Sodium Salt A selective, competitive antagonist of leukotriene D4</sub> (LTD4</sub>) (K<sub>i</sub> = 2.1 nM for inhibition of [³H]LTD4</sub> binding to human lung membranes).	Buy
Cayman Chemical 10029	1mg	$36	MK-571 ≥95%	Buy
Cayman Chemical 10029	5mg	$77	MK-571 ≥95%	Buy
Cayman Chemical 10029	10mg	$132	MK-571 ≥95%	Buy

(E)-3-[[[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-[[(3-dimethylamino)-3-oxopropyl]thio]methyl]thio]-propanoic acid, sodium salt Chemical Properties,Usage,Production

Description

MK-571 is a selective, orally active CysLT₁ receptor antagonist. It blocks the binding of LTD₄, but not LTC₄, to human and guinea pig lung membranes with K_i values of 0.22 nM and 2.1 nM, respectively, which is indicative of CysLT₁ receptor-mediated activity in these preparations. MK-571 effectively blocks LTD₄ activation of recombinant human and murine CysLT₁ receptors but is ineffective at blocking LTC₄ or LTD₄ activation of the recombinant human or murine CysLT₂ receptors.

Chemical Properties

Yellow Solid

Uses

A receptor antagonist for the treatment of respiratory diseases. Cysteinyl leukotriene receptor antagonist MK-571 alters bronchoalveolar lavage fluid proteome in asthma.

Definition

ChEBI: MK 571 is a member of quinolines.

Biological Activity

Potent CysLT 1 (LTD 4 ) leukotriene receptor inverse agonist (EC 50 = 1.3 nM). Antagonizes LTD 4 -induced contractions of guinea pig trachea and ileum (pA 2 values are 9.4 and 10.5 respectively). Also inhibitor of multidrug resistance protein-1 (MRP1) mediated transport; in vitro augments the effects of cytotoxic agents on malignant cells.

storage

Store at -20°C

References

[1] T R JONES. Pharmacology of L-660,711 (MK-571): a novel potent and selective leukotriene D4 receptor antagonist.[J]. Canadian journal of physiology and pharmacology, 1989, 67 1: 17-28. DOI:10.1139/y89-004
[2] DENIS J DUPRÉ. Inverse agonist activity of selected ligands of the cysteinyl-leukotriene receptor 1.[J]. Journal of Pharmacology and Experimental Therapeutics, 2004, 309 1: 102-108. DOI:10.1124/jpet.103.059824
[3] E VELLENGA. Interleukin-6 production by activated human monocytic cells is enhanced by MK-571, a specific inhibitor of the multi-drug resistance protein-1.[J]. British Journal of Pharmacology, 1999, 127 2: 441-448. DOI:10.1038/sj.bjp.0702577

Preparation Products And Raw materials

(E)-3-[[[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-[[(3-dimethylamino)-3-oxopropyl]thio]methyl]thio]-propanoic acid, sodium salt Supplier

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	9920	65
UHN Shanghai Research & Development Co., Ltd.	021-58958002 18930822973	sales@uhnshanghai.com	China	997	58
Shanghai Tauto Biotech Co., Ltd.	021-51320588	tauto@tautobiotech.com	China	3984	66
TargetMol Chemicals Inc.	021-021-33632979 15002134094	marketing@targetmol.com	China	7993	58
AdooQ Bioscience CHINA	025-58849295	info@adooq.cn	China	2981	60
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51389	80

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