Description
This Mitragyna alkaloid has been isolated from the leaves of M. speciosa Korth
by Beckett and his colleagues. It is an amorphous solid which cannot be obtained
crystalline. The base may be characterized as the picrate which forms pale yellow
needles from MeOH, m.p. 223°C (dec.). A methylgroup, a methoxycarbonyl
group and one imino group are present. The second nitrogen atom is tertiary.
Uses
Isomitraphylline is an oxoindole alkaloid derivied from amazonian plants and maintain medicinal benefits. Used in the treatment of ulcers, arthritis, etc.
References
[1] Beckett et al., J. Pharm. Pharmacol., 17,753 (1965)
[2] Beckett et ai., Planta Med., 14, 266 (1966)
[3] Structure:
[4] Finch, Taylor., J. Amer. Chem. Soc., 84,3871 (1962)
[5] Prepara tion:
[6] Seaton et al., Can. J. Chem., 38, 1035 (1960)
[7] [1] L DINAN. Assessment of natural products in the Drosophila melanogaster B(II) cell bioassay for ecdysteroid agonist and antagonist activities.[J]. Psychological Reports, 2001, 8 1: 321-342. DOI:
10.1007/pl00000859[8] [2] NICOLE BACHER. Oxindole alkaloids from Uncaria tomentosa induce apoptosis in proliferating, G0/G1-arrested and bcl-2-expressing acute lymphoblastic leukaemia cells[J]. British Journal of Haematology, 2006, 132 5: 615-622. DOI:
10.1111/j.1365-2141.2005.05907.x
