Description
20-
hydroxy Prostaglandin F
2α (20-
hydroxy PGF
2α) is the ω-
oxidation product of PGF
2α. Cultured type II alveolar cells from pregnant rabbits metabolize exogenous PGF
2α via microsomal cytochrome P450 ω-
oxidation, producing 20-
hydroxy PGF
2α and its 15-
hydroxy PGDH metabolites. Cells from male rabbits exhibit only the 15-
hydroxy PGDH pathway.
1
References
1. Devereux, T.R., Fouts, J.R., and Eling, T.E.
Metabolism of prostaglandin PG-F2α by freshly isolated alveolar type II cells from lungs of adult male or pregnant rabbits Prostaglandins Leukot. Med. 27,43-52(1987).