4-(Trifluoromethyl)benzylamine

Chemical Properties

Uses

Synthesis

16939-49-4

3300-51-4

General procedure for the synthesis of 4-(trifluoromethyl)benzylamine from the compound (CAS:16939-49-4): 5.00 g (26.4 mmol) of 4-trifluoromethylbenzaldehyde oxime was dissolved in methanol, followed by the addition of 4.0 g (109.7 mmol) of hydrogen chloride gas and 252 mg of the same catalyst as in Example 1, and the reaction was carried out with continuous stirring for 3 hours. The reaction was carried out at 10 atm hydrogen pressure and room temperature (about 25°C). Upon completion of the reaction, the catalyst was removed and ether was added to the reaction mixture and neutralized with aqueous sodium hydroxide. Analysis of the separated ether layer by gas chromatography confirmed the formation of 4-trifluoromethylbenzylamine in 93.6% yield.

References