Synthesis
GENERAL METHOD: Under stirring conditions, azide derivatives 9a or 9b (4.03 mmol) were dissolved in THF (1 mL), followed by the addition of solid triphenylphosphine (Ph3P, 4.03 mmol) and water (H2O, 6.04 mmol). The reaction mixture was stirred continuously for 12 h at room temperature. After completion of the reaction, the solvent was removed by concentration under reduced pressure. The crude product was purified by rapid column chromatography on silica gel with an eluent ratio of methanol-dichloromethane (9:1).
References
[1] Synthesis, 2005, # 14, p. 2407 - 2413
[2] Angewandte Chemie - International Edition, 2011, vol. 50, # 48, p. 11382 - 11385
[3] Synthetic Communications, 2011, vol. 41, # 17, p. 2517 - 2523
[4] Tetrahedron Letters, 2010, vol. 51, # 40, p. 5281 - 5286
[5] Phosphorus, Sulfur and Silicon and the Related Elements, 2013, vol. 188, # 4, p. 509 - 511
