Description
Fluoroclebopride is a benzamide analog that is used in positron emission tomography (PET) applications. It binds reversibly to dopamine receptors (K
is = 0.95, 5.7, 5.46, and 144 nM for D
2-like, D
2(long), D
3, and D
4 receptors, respectively, in radioligand binding assays). It is selective for these receptors over D
1, serotonin 5-HT
2, and α
2-adrenergic receptors (K
is = >10,000, 283, and 1,300 nM, respectively). A fluorine-18 moiety has been used to label this compound for use as a probe for studying D
2/D
3 receptor availability
via PET in various monkey models.