154540-49-5

Fluoroclebopride is a benzamide analog that is used in positron emission tomography (PET) applications. It binds reversibly to dopamine receptors (K_is = 0.95, 5.7, 5.46, and 144 nM for D₂-like, D_2(long), D₃, and D₄ receptors, respectively, in radioligand binding assays). It is selective for these receptors over D₁, serotonin 5-HT₂, and α₂-adrenergic receptors (K_is = >10,000, 283, and 1,300 nM, respectively). A fluorine-18 moiety has been used to label this compound for use as a probe for studying D₂/D₃ receptor availability via PET in various monkey models.

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