Description
Oligomycin D is a macrolide antibiotic produced by several species of
Streptomyces that inhibits the mitochondrial F
1F
O-ATPase and is used to uncouple oxidative phosphorylation from electron transport. Oligomycin D is reported to inhibit K-Ras plasma membrane localization in MDCK cells with an IC
50 value of 3.49 nM and is cytotoxic to SW620 colon cancer cells with an IC
50 value of 36 μM.
Uses
Oligomycin D (rutamycin) is macrocyclic lactone belonging to the oligomycin class but identified from different species of Streptomyces in 1961. Like oligomycin A, oligomycin D inhibits mitochondrial F1F0-ATPase and is an important bioprobe to study the organisation of ATPase on the mitochondrial membrane. Oligomycin D exhibits a broad biological profile including antifungal, antitumor and nematocidal activities.
