Description
Penicillin V-d
5 is intended for use as an internal standard for the quantification of penicillin V by GC- or LC-MS. Penicillin V is a β-lactam antibiotic that inhibits the growth of bacteria.
1,2,3 In vitro, penicillin V inhibits the growth of clinical isolates of
Streptococci (MICs = 0.004-0.008 mg/L) and
C. difficile (MICs = 1 to >256 mg/L).
1,2 Penicillin V also inhibits growth of
S. aureus in vitro (MIC = 0.016 mg/L) and
in vivo in a thigh model of infection in mice.
3 It inhibits the growth of
S. pyogenes in mice following one or two dose therapy with curative dose (CD
50) values of 0.207 and 0.031 mg, respectively.
4 Penicillin V (100 mg/kg per day, p.o.) prevents experimental acute otitis media in rats when administered prior to infection by pneumococci.
5 Formulations containing penicillin V have been used to treat bacterial infections of the skin, throat, ear, mouth, and respiratory tract.
Uses
Penicillin V-d5 (potassium) is the deuterium labeled Penicillin V Potassium[1]. Penicillin V Potassium (Phenoxymethylpenicillin potassium salt) is an orally active antibiotic. Penicillin V Potassium inhibits the growth of Streptococci, C. difficile and S. aureus. Penicillin V Potassium can be used for the research of otitis, sinusitis, pharyngitis and tonsillitis[2][3][4][5].
References
1. Kamme, C., and Petersson, A.C.
In vitro effect on group A streptococci of loracarbef versus cefadroxil, cefaclor and penicillin V Scand. J. Infect. Dis. 25(1),37-42(1993).
2. Norén, T., Alriksson, I., Akerlund, T., et al.
In vitro susceptibility to 17 antimicrobials of clinical Clostridium difficile isolates collected in 1993-2007 in Sweden Clin. Microbiol. Infect. 16(8),1104-1110(2010).
3. Overbosch, D., Mattie, H., and Van Furth, R.
Comparative pharmacodynamics and clinical pharmacokinetics of phenoxymethylpenicillin and pheneticillin Br. J. Clin. Pharmacol. 19(5),657-668(1985).
4. Powell, H.M., and Culbertson, C.G.
Effectiveness of phenoxymethyl penicillin V, and sodium penicillin G against hemolytic Streptococcus infection in white mice Proc. Soc. Exp. Biol. Med. 90(1),186-187(1955).
5. Hermansson, A., Prellner, K., and Hellstrm, S.
Prevention of experimental acute otitis media with penicillin V Acta Otolaryngol. 109(1-2),119-123(1990).
