1-(3,4-Dimethylphenyl)piperazine

Chemical Properties

1-(3,4-Dimethylphenyl)piperazine is a light beige to faintly yellow crystalline powder,the enantioselectivity and yields are high when it is used in the ring-opening reaction with an aliphatic allylic amine. This reaction is also efficient with nucleophiles such as primary amines or alcohols.

Uses

1-(3,4-Dimethylphenyl)piperazine is a chiral building block for the synthesis of polysubstituted piperazines. It can be used as a bridgehead to synthesize asymmetric amines.