Obexelimab
- Product NameObexelimab
- CAS1690307-05-1
- CBNumberCB08080918
- MW0
- MOL FileMol file
- MSDS FileSDS
Obexelimab Price
| Product number | Packaging | Price | Product description | Buy |
|---|---|---|---|---|
| ChemScene CS-0629183 | 1mg | $433 | Obexelimab 99.99% |
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| ChemScene CS-0629183 | 5mg | $1300 | Obexelimab 99.99% |
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| ChemScene CS-0629183 | 10mg | $2058 | Obexelimab 99.99% |
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| aablocks AA02DJLR | 1mg | $664 | Obexelimab ≥95%(SDS-PAGE&SEC-HPLC) |
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| aablocks AA02DJLR | 5mg | $2000 | Obexelimab ≥95%(SDS-PAGE&SEC-HPLC) |
Buy |
Obexelimab Chemical Properties,Usage,Production
Uses
Obexelimab (XmAb5871) is a humanized anti-CD19 antibody. Obexelimab works by inhibiting B cell receptor (BCR) mediated calcium influx and promoting the phosphorylation of Fc γ receptor IIb (FcγRIIb), which reduces B cell activation and function, leading to B cell apoptosis. Obexelimab can be used in research for rheumatoid arthritis and systemic lupus erythematosus[1][2][3].in vivo
Obexelimab (10 mg/kg; twice a week; i.p.) can inhibit the autoimmune response of immune deficient mice implanted with peripheral blood mononuclear cells (PBMCs) from rheumatoid arthritis (RA) patients[2].
| Animal Model: | Female C.B-17 SCID mice transplanted with PBMCs[2]. |
| Dosage: | 10 mg/kg |
| Administration: | Intraperitoneal injection (i.p.); twice a week |
| Result: | Resulted in inhibition of various immune responses in mice, including IgG, IgM, RF, ACPA, and anti-tetanus antibodies. |
References
[1] Boyles JS, et al. A nondepleting anti-CD19 antibody impairs B cell function and inhibits autoimmune diseases. JCI Insight. 2023 Jul 10;8(13):e166137. DOI:10.1172/jci.insight.166137[2] Chu SY, et al. Suppression of rheumatoid arthritis B cells by XmAb5871, an anti-CD19 antibody that coengages B cell antigen receptor complex and Fcγ receptor IIb inhibitory receptor. Arthritis Rheumatol. 2014 May;66(5):1153-64. DOI:10.1002/art.38334
[3] Horton HM, et al. Antibody-mediated coengagement of FcγRIIb and B cell receptor complex suppresses humoral immunity in systemic lupus erythematosus. J Immunol. 2011 Apr 1;186(7):4223-33. DOI:10.4049/jimmunol.1003412
Preparation Products And Raw materials
Obexelimab Suppliers
Global(18)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 15026964105 | 2881489226@qq.com | China | 89667 | 60 | |
| 177-54423994 17754423994 |
2853530910@QQ.com | China | 8000 | 62 | |
| 15817493340 | 981810490@qq.com | China | 1577 | 58 | |
| 027-65317797 15926423062 |
422450190@qq.com | China | 10305 | 58 | |
| 010-60605840 | psaitong@jm-bio.com | China | 27626 | 58 | |
| 4008200310 15002144251 |
marketing@tsbiochem.com | China | 24951 | 58 | |
| 027-65279366 18108604356 |
products@biolabreagent.com | China | 9864 | 58 | |
| 13720134139 086-15871494362 13720134139 |
orders@jknbiochem.com | China | 7283 | 58 | |
| 021-65675885 18964387627 |
customer_service@efebio.com | China | 11963 | 58 | |
| 027-027-16602739303 16602739303 |
673003916@qq.com | China | 4593 | 58 |
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