H-Val-Pro-Leu-OH

Uses

Diprotin B is a dipeptidyl aminopeptidase IV (DPP IV) inhibitor. The apparent competitive inhibition of DPP-IV by the diprotins is a kinetic artifact, derived from the substrate-like nature of tripeptides containing a penultimate proline residue[1][2].

Definition

ChEBI: Val-Pro-Leu is an oligopeptide.

References

[1] Rahfeld J, et al. Are diprotin A (Ile-Pro-Ile) and diprotin B (Val-Pro-Leu) inhibitors or substrates of dipeptidyl peptidase IV Biochim Biophys Acta. 1991 Jan 29;1076(2):314-6. DOI:10.1016/0167-4838(91)90284-7
[2] Hatanaka T, et al. Inhibitory effect of collagen-derived tripeptides on dipeptidylpeptidase-IV activity. J Enzyme Inhib Med Chem. 2014 Dec;29(6):823-8. DOI:10.3109/14756366.2013.858143