Chemical Properties
White-to-Off White Powder
Uses
A potent and selective agonist of the excitatory neurotransmitter L-glutamic Acid. AMPA does not interfere with binding sites for kainic acid in vitro, and AMPA- induced neuronal excitation is not significantly affected by NMDA antagonists
Uses
AMPA is the defining agonist for the AMPA subgroup of ionotropic glutamate receptors, which mediate excitatory neurotransmission. Because AMPA does not interfere with binding sites for kainic acid or NMDA , it can be used to distinguish AMPA receptor-specific activity that contributes to a neuronal response. (R,S)-AMPA contains an equal mixture of the active (S)-enantiomer and the inactive (R)-enantiomer.
Definition
ChEBI: (S)-AMPA is a non-proteinogenic alpha-amino acid.
Biological Activity
More water soluble hydrobromide salt of ( RS )-AMPA ((RS)-a-Amino-3-hydroxy-5-methyl-4-isoxazolepropionicacid ).
