Uses
Active enantiomer of AMPA that induces apoptosis in cortical neurons
Uses
(
S)-AMPA has also been used to activate rostromedial tegmental nucleus (RMTg), to study aversive conditioning in relation with cocaine-induced avoidance behaviors in mice.
Uses
(S)-AMPA is an analogue for AMPA (A611500) a specific agonist for the AMPA receptor which mimics the glutamate receptor.
General Description
AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) activates excitatory postsynaptic currents (EPSC).
Biological Activity
Active enantiomer of AMPA (EC 50 = 3.5 μ M). Also available as part of the AMPA Receptor Tocriset™ .
Biochem/physiol Actions
Active enantiomer of (RS)-AMPA zwitterion. Potent agonist at the AMPA subclass of ionotropic glutamate receptors.
