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CYCLOTHIAZIDE

CYCLOTHIAZIDE Structure
CYCLOTHIAZIDE
  • CAS No.2259-96-3
  • Chemical Name:CYCLOTHIAZIDE
  • CBNumber:CB6123851
  • Molecular Formula:C14H16ClN3O4S2
  • Formula Weight:389.88
  • MOL File:2259-96-3.mol
CYCLOTHIAZIDE Property
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements
CYCLOTHIAZIDE Price More Price(28)
  • Brand: Sigma-Aldrich
  • Product number: C9847
  • Product name : Cyclothiazide
  • Purity: 
  • Packaging: 10mg
  • Price: $103
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: 1159008
  • Product name : Cyclothiazide
  • Purity: United States Pharmacopeia (USP) Reference Standard
  • Packaging: 200mg
  • Price: $350
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: TCI Chemical
  • Product number: C3392
  • Product name : Cyclothiazide (mixture of isomers)
  • Purity: >95.0%(HPLC)
  • Packaging: 25mg
  • Price: $138
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: TCI Chemical
  • Product number: C3392
  • Product name : Cyclothiazide (mixture of isomers)
  • Purity: >95.0%(HPLC)
  • Packaging: 100mg
  • Price: $410
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: Cayman Chemical
  • Product number: 16335
  • Product name : Cyclothiazide
  • Purity: ≥95%
  • Packaging: 10mg
  • Price: $35
  • Updated: 2021/12/16
  • Buy: Buy

CYCLOTHIAZIDE Chemical Properties,Usage,Production

  • Originator Anhydron,Lilly,US,1963
  • Uses Diuretic; antihypertensive. A subunit-specific inhibitor of GABAC receptors.
  • Uses Diuretic; antihypertensive. A subunit-specific inhibitor of GABAC receptors
  • Definition ChEBI: 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted at positions 3, 5 and 6 by a 2-norbornen-5-yl group, chlorine, and a sulfonamide group, respectively. A thiazide diuretic, it has been used in the management of hypertension a d oedema.
  • Manufacturing Process A mixture of 8.5 g (0.03 mol) of 6-chloro-4-amino-benzene-1,3- disulfonamide, 4.0 g (0.033 mol) of 2,5-endomethylene-δ3- tetrahydrobenzaldehyde and 25 cc of diethyleneglycol-dimethyl ether was heated for 2 hours at 100°C. During this time the major portion of the initially undissolved crystals went into solution; thereafter, the reaction mixture was allowed to stand for 14 hours at room temperature, during which the remaining undissolved crystals also went into solution. The reddish, clear solution thus obtained was admixed with 50 cc of chloroform. The greyishwhite precipitate formed thereby was separated by vacuum filtration, washed with a small amount of chloroform, dried and recrystallized from aqueous methanol. 7.5 g of white crystalline needles having a melting point of 229° to 230°C were obtained.
  • brand name Anhydron (Lilly).
  • Therapeutic Function Diuretic, Antihypertensive
  • Biological Activity Positive allosteric modulator of AMPA receptors that potently inhibits AMPA receptor desensitization. Selective for the flip variant of each of the four receptor subunits. Also available as part of the AMPA Receptor Tocriset™ .
CYCLOTHIAZIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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2259-96-3, CYCLOTHIAZIDERelated Search:
  • 2,4-benzothiadiazine-3-bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-4-dihydro-2h-1
  • 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3,4-dihydro-6-chloro-3-(5-norbornen-2-yl)-,1,1-dioxide
  • 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3-bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-3,4-dihydro-, 1,1-dioxide
  • 2h-1,2,4-benzothiadiazine-7-sulfonamide,3-bicyclo(2.2.1)hept-5-en-2-yl-6-chlor
  • 35483
  • 4-benzothiadiazine-7-sulfonamide,3,4-dihydro-6-chloro-3-(5-norbornen-2-2h-2
  • mdi193
  • o-3,4-dihydro-,1,1-dioxide
  • Renazide
  • Valmiran
  • CYCLOTHIAZIDE
  • 3-BICYCLO[2.2.1]HEPT-5-EN-2-YL-6-CHLORO-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE 1,1-DIOXIDE
  • 6-CHLORO-3,4-DIHYDRO-3-[2-NORBORNEN-5-YL]-2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE 1,1-DIOXIDE
  • 6-CHLORO-3,4-DIHYDRO-3-(5-NORBORNEN-2-YL)-2H-1,2,4-BENZOTHIAZIDIAZINE-7-SULFONAMIDE-1,1-DIOXIDE
  • 6-CHLORO-3,4-DIHYDRO-3-(NORBORNER-5-YL)-2H-1,2,4-BENZOTHIADIAZINE
  • 6-CHLORO-3,4-DIHYDRO-3-(NORBORNER-5-YL)-2H-1,2,4-BENZOTHIADIAZINE-7-SULPHONAMIDE-1,1-DIOXIDE
  • 6-chloro-3,4-dihydro-3-(8,9,10-trinorborn-5-en-2-yl)-2H-1,2,4-benzothiadiazine-7-sulphonamide 1,1-dioxide
  • Anhydrom
  • Aquador
  • 3-(6-bicyclo[2.2.1]hept-2-enyl)-6-chloro-1,1-diketo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide
  • 3-(6-bicyclo[2.2.1]hept-2-enyl)-6-chloro-1,1-dioxo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide
  • 4-benzothiadiazine-7-sulfonamide,6-chloro-3,4-dihydro-3-(5-norbornen-2-2h-2
  • 6-chloro-3-(2-norbornen-5-yl)-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine1,1
  • 6-chloro-3,4-dihydro-3-(2-norbornen-5-yl)-2h-1,2,4-benzothiadiazine-7-sulfonam
  • 6-chloro-3,4-dihydro-3-(2-norbornen-5-yl)-7-sulfamoyl-1,2,4-benzothiadiazine1,
  • 6-Chloro-3,4-dihydro-3-(5-norbornen-2-yl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
  • 7-sulfonamide1,1-dioxide
  • Anhydron
  • Aquirel
  • Doburil
  • Fluidil
  • Lilly 35483
  • lilly35,483
  • MDi 193
  • Cyclothiazide (200 mg) (AS)
  • Lil
  • 3-((1S,4S)-bicyclo[2.2.1]hept-5-en-2-yl)-6-chloro-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonaMide 1,1-dioxide
  • Cyclothiazide (mixture of isomers)
  • CYCLOTHIAZIDE USP/EP/BP
  • 2259-96-3
  • C14H16ClN3O4S2
  • C14H16N3O4S2Cl
  • Cell Signaling and Neuroscience
  • Cell Biology
  • BioChemical
  • Ligand-Gated Ion Channels
  • Ionotropic Glutamate Receptor Modulators
  • Ion Channels
  • Glutamate
  • Glutamate receptor
  • Amines
  • Heterocycles
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Sulfur & Selenium Compounds