Synthesis
General procedure for the synthesis of diethyl 4-bromobenzylphosphonate (16) from p-bromobenzyl bromide and triethyl phosphite: 1-bromo-4-(bromomethyl)benzene (5.0 g, 20 mmol) and triethyl phosphite (51 mL, 300 mmol) were added to a round-bottomed flask, and the mixture was reacted by refluxing the reaction for 19 hours at 90 °C. Upon completion of the reaction, the excess triethyl phosphite was removed by distillation under reduced pressure. The crude product was purified by fast column chromatography (eluent ratio 1:1 hexane/ethyl acetate) to afford the target compound 16 in 98% yield. The product was a colorless liquid; 1H NMR (400 MHz, CDCl3) δ 7.30 (d, 2H, J = 7.5 Hz), 7.05 (d, 2H, J = 7.6 Hz), 3.99-3.88 (m, 4H), 2.99 (s, 1H), 2.94 (s, 1H), 1.12 (t, 6H, J = 6.9 Hz); 13C NMR ( 100 MHz, CDCl3) δ 131.7, 131.6, 131.5, 121.0, 62.3, 34.0, 32.0, 16.5; HRMS calculated value (C11H16BrO3P, [M + H]+) 307.0097, measured value 307.0093.
References
[1] Patent: US6689922, 2004, B1. Location in patent: Page column 23
[2] Chemistry - A European Journal, 2012, vol. 18, # 24, p. 7473 - 7485
[3] Synthetic Communications, 2011, vol. 41, # 2, p. 206 - 218
[4] Patent: US2013/41153, 2013, A1. Location in patent: Paragraph 0041; 0042; 0043; 0044
[5] ChemMedChem, 2010, vol. 5, # 1, p. 56 - 60
