Description
UDMH is a fuming colorless liquid that turnsyellow on contact with air, with a fishy, amine-like odor.The odor threshold is 6.114 ppm. Molecularweight= 60.12; Boiling point = 63.9℃; Freezing/Meltingpoint = 257.7℃; Vapor pressure= 103 mmHg at 20℃;Flash point = 215℃; Autoignition temperature= 249℃.Explosive limits: LEL = 2.0%; UEL= 95%. HazardIdentification (based on NFPA-704 M Rating System):Health 4, Flammability 3, Reactivity 1. Highly soluble inwater.
Chemical Properties
1,1-Dimethylhydrazine is a colorless, flammable, hygroscopic liquid that gradually turns
yellow on contact with air and is miscible with water. 1,1-Dimethylhydrazine is primar-
ily used as a high-energy fuel in military applications, as a rocket propellant and fuel for
thrusters, and small electrical power-generating units. 1,1-Dimethylhydrazine is also used
in the manufacture of a plant growth regulator, in chemical synthesis, in photographic
chemicals, as a stabilizer for fuel additives, and as an absorbent for acid gases. Exposure
to 1,1-dimethylhydrazine usually occurs at the workplace during use and handling of the
chemical substance.
No information is available on the carcinogenic effects of 1,1-dimethylhydrazine in humans.
Carcinogenic effects were observed in mice and rats exposed to 1,1-dimethylhydrazine
by inhalation, but the carcinogenicity could not be defi nitively attributed to
1,1-dimethylhydrazine because of the presence of contaminants in the study. The US EPA
has not classifi ed 1,1-dimethylhydrazine for potential carcinogenicity, while the IARC has
classifi ed 1,1-dimethylhydrazine as Group 2B, meaning a possible human carcinogen.
Physical properties
Clear, colorless fuming liquid with an amine-like odor. Turns yellow on exposure to air. Odor
detection threshold concentrations ranged from 6.1 to 14 ppm
v (Jacobson et al., 1955).
Uses
N,N-Dimethylhydrazine is used as a reagent in the synthesis of novel substituted pyridinylbenzenesulfonamide derivatives which have herbicidal activity. N,N-Dimethylhydrazine is also used in the preparation of the antibacterial agent, (-)-Platencin.
Uses
Base in rocket fuel formulations; intermediate
in organic synthesis
Uses
1,1-Dimethylhydrazine is used in rocket fuel.
Definition
ChEBI: A member of the class of hydrazines that is hydrazine substituted by two methyl groups at position 1.
General Description
A clear colorless liquid with an ammonia-like odor. Flash point 0°F. Corrosive to the skin. Less dense than water and soluble in water. Vapors are heavier than air and very toxic by inhalation, attacking the eyes and respiratory system. Prolonged exposure of containers to heat may result in their violent rupturing and rocketing due to decomposition. Generates toxic oxides of nitrogen when burned. Vapors may travel to a source of ignition and a flame can flashback to the source of vapors. Used as a rocket propellant and to make other chemicals.
Air & Water Reactions
Highly flammable over a wide range of vapor concentrations. May ignite spontaneously when spread on a large surface exposed to the air. [Def. Res. and Eng., pp 299-300(1963)]. Dissolves and slowly decomposes in water.
Reactivity Profile
1,1-Dimethylhydrazine is a powerful reducing agent. Ignition can occur on contact with oxidizing agents such hydrogen peroxide and fuming nitric acid, [Haz. Chem. Data(1966)]. Also reacts as a base to neutralize acids in exothermic reactions.
Health Hazard
1,1-Dimethylhydrazine exhibits high acute toxicity as a result of exposure by all routes. Death or permanent injury may result after very short exposure to small quantities. Chronic exposure may cause pneumonia, liver damage, and kidney damage.
Health Hazard
The vapors of this compound are irritating tothe eyes, nose, and throat. The liquid is corrosive to the skin. The toxic properties aresimilar to those of 1,1-dimethylhydrazine.Exposure to 280 ppm for 4 hours was fatalto rats. The oral LD50 value in th.
Fire Hazard
Vapor may explode if ignited in an enclosed area. Vapors may travel to a source of ignition and flashback. Runoff to sewer may create fire or explosion hazard. When 1,1-Dimethylhydrazine decomposes, 1,1-Dimethylhydrazine gives off toxic nitrogen compound fumes. Dissolves, swells, and disintegrates many plastics. Dangerous when exposed to heat, flame, or oxidizers. Hazardous polymerization may not occur.
Safety Profile
Confirmed carcinogen
with experimental carcinogenic,
tumorigenic, and teratogenic data. Other
experimental reproductive effects. Poison byingestion, intraperitoneal, intravenous, and
intracerebral routes. Moderately toxic by
inhalation and skin contact. Human
mutation data reported. A plant growth
control agent. Corrosive. A powerful
reducing agent. A dangerous fire hazard. It
is hypergolic with many oxidants (e.g.,
dinitrogen tetroxide, hydrogen peroxide, and
nitric acid). Dangerous when exposed to
heat, flame, or oxidizers; can react
vigorously with oxidning materials such as
air, fuming HNO3, (HNO3 + N2O4), NO. A
high-energy propellant for liquid-fueled
rockets. To fight fire, use alcohol foam,
CO2, dry chemical. When heated to
decomposition it emits highly toxic fumes of
NOx. See also HYDRAZINE.
Potential Exposure
Tumorigen,Mutagen; Reproductive Effector; Human Data. This material is used as a component in liquid rocket propellant combinations; it is also used in photography; as an absorbent;and to make other chemicals.
First aid
If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medical attention. If victim is conscious, administer water ormilk. Do not induce vomiting. Medical observation isrecommended for 2448 h after breathing overexposure, aspulmonary edema may be delayed. As first aid for pulmonary edema, a doctor or authorized paramedic may consideradministering a corticosteroid spray.
Carcinogenicity
1,1-Dimethylhydrazine is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.
Environmental Fate
Chemical/Physical. Releases toxic nitrogen oxides when heated to decomposition (Sax and
Lewis, 1987). Ignites spontaneously in air or in contact with hydrogen peroxide, nitric acid, or
other oxidizers (Patnaik, 1992).
N-Nitrosodimethylamine was the major product of ozonation of 1,1-dimethylhydrazine in the
dark. Hydrogen peroxide, methyl hydroperoxide, and methyl diazene were also identified (HSDB,
1989).
storage
(1) Color Code—Red: Flammability Hazard: Storein a flammable liquid storage area or approved cabinetaway from ignition sources and corrosive and reactivematerials. (2) Color Code—Yellow Stripe (strong reducingagent): Reactivity Hazard; Store separately in an area isolated from flammables, combustibles, or other yellow-codedmaterials. (3) Color Code—Blue: Health Hazard/Poison:Store in a secure poison location. Prior to working withUDMH you should be trained on its proper handling andstorage. Outside or detached storage is preferred. Beforeentering confined space where this chemical may be present, check to make sure that an explosive concentrationdoes not exist. Store in tightly closed containers in a cool,well-ventilated area. Keep dry and separate from porousmaterials, oxidizing agents, and other incompatible materials, some of which are listed above. Store in an inert atmosphere below 50℃. Do not use copper containers. Metalcontainers involving the transfer of this chemical should begrounded and bonded. Where possible, automatically pumpliquid from drums or other storage containers to processcontainers. Drums must be equipped with self-closingvalves, pressure vacuum bungs, and flame arresters. Useonly nonsparking tools and equipment, especially whenopening and closing containers of this chemical. Sources ofignition, such as smoking and open flames, are prohibitedwhere this chemical is used, handled, or stored in a mannerthat could create a potential fire or explosion hazard.Wherever this chemical is used, handled, manufactured, orstored, use explosion-proof electrical equipment and fittings. A regulated, marked area should be established wherethis chemical is handled, used, or stored in compliance withOSHA Standard 1910.1045.
Shipping
This compound requires a shipping label of“POISONOUS/TOXIC MATERIALS, POISON GAS,CORROSIVE.” It falls in Hazard Class 6.1 and PackingGroup I. Procedures for the handling, use, and storage ofcylinders should be in compliance with OSHA 1910.101and 1910.169 with the recommendations of the CompressedGas Association.
Purification Methods
Fractionally distil the hydrazine through a 4-ft column packed with glass helices. Precipitate it as its oxalate from diethyl ether solution. After crystallising from 95% EtOH, the salt is decomposed with aqueous saturated NaOH, and the free base is distilled, dried over BaO and redistilled [McBride & Kruse J Am Chem Soc 79 572 1957]. Distillation and storage should be under nitrogen. [Beilstein 4 IV 3322.]
Incompatibilities
Forms explosive mixture with air; mayspontaneously ignite on contact with air and porous materials, such as asbestos, wood, earth, cloth, etc. Reacts withoxygen causing fire and explosion hazard. A strong reducing agent, this chemical is incompatible with strong acids,halogens, metallic mercury, copper alloys, brass, iron, ironsalts. Contact with strong oxidizers, such as nitric acid,nitrogen tetroxide, hydrogen peroxide, may cause spontaneous ignition. A strong base, this chemical is corrosive andreacts violently with acids. Attacks some plastics, rubber,and coatings. May accumulate static electrical charges, andmay cause ignition of its vapors
