Description
Imidocarb dipropionate is a propionate salt of imidazobenzuron, a potent antiprotozoal agent. It is commonly used in animals like horses, where it is found to be effective in inhibiting the Theileria equi strains causing infections.
Chemical Properties
White or off white crystalline powder
Uses
Imidocarb dipropionate is an antibiotic and diaminide of the carbanilide series of antiprotozoal compounds. It is used for the treatment and prevention of various diseases caused by Babesiosis, Pyriformes, Trypanosomes, Erythrocytes, Marginal Edge Worms and Taylor Worms.
Indications
For the treatment of dogs with clinical signs of babesiosis and/or demonstrated Babesia organisms in the blood.
Definition
Imidocarb dipropionate (Carbesia?, Carbésia?, Forray?, Imidox?, Imizol?) is a carbanilide derivative with antiprotozoal activity, marketed only for veterinary use. It is the most commonly used drug against Hepatozoon infections, and it also is used for the treatment of Trypanosoma brucei and Babesia ovis. Its mode of action is uncertain, but it has been suggested that it acts against T. brucei by interfering with polyamine production and against B. ovis by blocking the entrance of inositol into erythrocytes. Imidocarb dipropionate is eliminated via urine and feces. It is usually administered as the dipropionate salt and is commercially available in injectable formulations for s.c. or i.m. administration.
Side effects
Imidocarb dipropionate may display severe adverse effects, from pain at the site of infection, vomiting, diarrhea, agitation, lethargy, periorbital swelling, and acute renal tubular necrosis or hepatic necrosis.
