ASP7663

Uses

ASP 7663 is a novel and selective transient receptor potential ankyrin 1 (TRPA1) agonist, which can be an effective anti-constipation drug with abdominal analgesic effect

Biological Activity

ASP7663 is a selective activator of transient receptor potential ankyrin 1 (TRPA1), known to play a role for chemical sensing in the pain pathway. ASP7663 activated human, rat, and mouse TRPA1 receptors with EC50 values of 510, 540, and 500 nM, respectively, and little or no affinity at more than 60 other related receptors, channels and enzymes. ASP7663 enhanced colonic motility and exerted analgesic effects against abdominal pain in mouse models.

storage

Store at +4°C