GSK-F1

Uses

GSK-F1 (Compound F1) is an orally active PI4KA inhibitor with pIC50 values of 8.0, 5.9, 5.8, 5.9, 5.9 and 6.4 against PI4KA, PI4KB, PI3KA, PI3KB, PI3KG and PI3KD, respectively. GSK-F1 can be used for HCV infection research[1].

IC 50

PI4KA: 8.0 (pIC₅₀); PI3KD: 6.4 (pIC₅₀); PI4KB: 5.9 (pIC₅₀); PI3KB: 5.9 (pIC₅₀); PI3KG: 5.9 (pIC₅₀); PI3KA: 5.8 (pIC₅₀)

References

[1] Bojjireddy N, et al. Pharmacological and genetic targeting of the PI4KA enzyme reveals its important role in maintaining plasma membrane phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate levels. J Biol Chem. 2014 Feb 28;289(9):6120-32. DOI:10.1074/jbc.M113.531426