ChemicalBook CAS DataBase List Tramadol hydrochloride

Tramadol hydrochloride

Product NameTramadol hydrochloride
CAS36282-47-0
CBNumberCB0251095
MFC16H25NO2.ClH
MW299.84
EINECS252-950-2
MDL NumberMFCD00798507
MOL File36282-47-0.mol
MSDS FileSDS

Chemical Properties

Melting point	178-181 °C
storage temp.	2-8°C
solubility	Freely soluble in water and in methanol, very slightly soluble in acetone.
pka	9.41
form	solid
color	white to off-white
InChI	1S/C16H25NO2.ClH/c1-17(2)12-14-7-4-5-10-16(14,18)13-8-6-9-15(11-13)19-3;/h6,8-9,11,14,18H,4-5,7,10,12H2,1-3H3;1H/t14-,16+;/m1./s1
InChIKey	PPKXEPBICJTCRU-XMZRARIVSA-N
SMILES	Cl.COc1cccc(c1)[C@@]2(O)CCCC[C@@H]2CN(C)C
NCI Dictionary of Cancer Terms	Ultram
FDA UNII	9N7R477WCK
NCI Drug Dictionary	Ultram
UNSPSC Code	41116107
NACRES	NA.25

Safety

Symbol(GHS)
Signal word	Warning
Hazard statements	H302-H411
Precautionary statements	P264-P270-P301+P312-P330-P501
Hazard Codes	Xn,N
Risk Statements	22-51/53
Safety Statements	61
RIDADR	UN 2811 6.1/PG 3
WGK Germany	2
HS Code	2922504500
Storage Class	6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects
Hazard Classifications	Acute Tox. 3 Oral Aquatic Chronic 2 STOT SE 3
Toxicity	mouse,LD50,intravenous,61700ug/kg (61.7mg/kg),Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 114, 1978.

Tramadol hydrochloride Price

Product number	Packaging	Price	Product description	Buy
Sigma-Aldrich PHR8812	200MG	$294	Tramadol hydrochloride pharmaceutical secondary standard, certified reference material	Buy
Sigma-Aldrich BP744	100MG	$256	Tramadol hydrochloride British Pharmacopoeia (BP) Reference Standard	Buy
Sigma-Aldrich 1672600	100MG	$584	Tramadol hydrochloride United States Pharmacopeia (USP) Reference Standard	Buy
Sigma-Aldrich 42965	1G	$89.8	Tramadol hydrochloride ≥99.0% (HPLC)	Buy
Sigma-Aldrich 42965	5G	$310	Tramadol hydrochloride ≥99.0% (HPLC)	Buy

Tramadol hydrochloride Chemical Properties,Usage,Production

Description

cis-Tramadol (Item No. 15919) is an analytical reference material categorized as an opioid. cis-Tramadol is regulated as a Schedule IV compound in the United States. This product is intended for research and forensic applications.

Description

cis-Tramadol (hydrochloride) (CRM) (Item No. ISO60149) is a certified reference material categorized as an opioid. cis-Tramadol is regulated as a Schedule IV compound in the United States. cis-Tramadol (hydrochloride) (CRM) (Item No. ISO60149) is provided as a DEA exempt preparation. This product is intended for research and forensic applications.

Chemical Properties

White Solid

Uses

An analgesic.

Uses

cis-Tramadol is an analgesic that activates the μ-opioid receptor (IC50 = 7.6 μM). It also inhibits serotonin and norepinephrine reuptake and blocks voltage-gated sodium channels. This product is intended for forensic and research applications.[Cayman Chemical]

Definition

ChEBI: (R,R)-tramadol hydrochloride is a hydrochloride resulting from the reaction of (R,R)-tramadol with 1 molar equivalent of hydrogen chloride; the (R,R)-enantiomer of the racemic opioid analgesic tramadol hydrochloride, it exhibits ten-fold higher analgesic potency than the (S,S)-enantiomer. It has a role as a delta-opioid receptor agonist, a kappa-opioid receptor agonist, a mu-opioid receptor agonist, an adrenergic uptake inhibitor, an antitussive, a capsaicin receptor antagonist, a muscarinic antagonist, a nicotinic antagonist, a NMDA receptor antagonist, an opioid analgesic, a serotonergic antagonist and a serotonin uptake inhibitor. It contains a (R,R)-tramadol(1+). It is an enantiomer of a (S,S)-tramadol hydrochloride.

References

[1] LIMING SHAO. Derivatives of tramadol for increased duration of effect[J]. Bioorganic & Medicinal Chemistry Letters, 2006, 16 3: Pages 691-694. DOI: 10.1016/j.bmcl.2005.10.024

Tramadol hydrochloride

Chemical Properties

Safety

Tramadol hydrochloride Price

Tramadol hydrochloride Chemical Properties,Usage,Production

Preparation Products And Raw materials

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