Chemical Properties
light yellow to light beige fine crystalline
Uses
8-Azahypoxanthine is an inhibitor of hypoxanthine-guanine phosphoribosyl transferase (HGPRT). 8-Azahypoxanthine has antitumor activity[1].
Definition
ChEBI: 8-azahypoxanthine is a triazolopyrimidine that consists of 1,4-dihydro-7H-[1,2,3]triazolo[4,5-d]pyrimidine bearing an oxo substituent at position 7. It has a role as an antimalarial and an EC 2.4.2.8 (hypoxanthine phosphoribosyltransferase) inhibitor. It is a nucleobase analogue and a member of triazolopyrimidines.
References
[1] M H Vaughan, et al. Differential sensitivity of human normal and malignant cells to 8-azahypoxanthine in vitro. Exp Cell Res. 1971, 69, 1. DOI:
10.1016/0014-4827(71)90314-4
