Chemical Properties
White powder
Uses
8-Bromoadenosine 3′,5′-cyclic monophosphate has been used:
- to treat H295R cells as positive controls for CYP19 induction
- as a membrane permeable cAMP analog to study its effect on short-circuit current (Isc)
- to investigate its potential as an inducer of differentiation in Wharton′s jelly-derived mesenchymal stem cells (WJ-MSCs)
Definition
ChEBI: A 3',5'-cyclic purine nucleotide that is 3',5'-cyclic AMP bearing an additional bromo substituent at position 8 on the adenine ring. An activator of cyclic AMP-dependent protein kinase.
Biochem/physiol Actions
8-bromo-adenosine?3′,5′-cyclic?monophosphate?(8-bromo-cAMP), added to hepatocytes during plating helps to increase the acquisition of beta-adrenoceptors.
