| Name | 8-Bromo-cAMP |
| Description | 8-Bromo-cAMP is a cell-permeable cAMP analogue and activator of CAMP-dependent protein kinase A that induces cell death and reduces proliferation. |
| In vitro | In primary rat renal tubular epithelial cells, 8-Bromo-cAMP (0.1 mM, 48 h) significantly increased both mRNA and protein levels of Na⁺-K⁺-ATPase α1 and β1 subunits, and promoted their membrane localization, suggesting enhancement of tubular ion transport via PKA signaling[1]. In NRK-52E rat renal proximal tubule epithelial cells, 8-Bromo-cAMP (10⁻⁶–10⁻³ mol/L, 48 h) significantly increased protein and mRNA levels of Na⁺-K⁺-ATPase α1 and β1 subunits (most prominently at 10⁻⁴ mol/L), and promoted their membrane localization, suggesting regulation via the cAMP/PKA signaling pathway[2]. |
| In vivo | In renal denervation rat models, 8-Bromo-cAMP (0.5 mmol/L, perfused via the left renal artery at 0.05 mL/min for 60 min) significantly increased expression of Na⁺-K⁺-ATPase α1 and β1 subunits in the renal cortex, indicating its ability to enhance sodium pump activity and support renal ion transport in vivo[2]. |
| Storage | keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | PBS (pH 7.2) : 2 mg/mL (4.9 mM), Sonication is recommended.
1 M NaOH : 80 mg/mL (196.03 mM), Sonication is recommended.
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| Keywords | 8-bromo-Cyclic AMP | 8bromoCyclic AMP | 8 bromo Cyclic AMP |
| Inhibitors Related | Stavudine | Cysteamine hydrochloride | Sodium 4-phenylbutyrate | Metronidazole | Citric Acid Triammonium | Tributyrin | L-Methionine | Sodium citrate | Cystamine dihydrochloride | L-Ascorbic acid sodium salt | Alginic acid | Dextran sulfate sodium salt (MW 5000) |
United States
