Neurotoxicity and Nephrotoxicity
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COLISTIN

Neurotoxicity and Nephrotoxicity
COLISTIN Structure
COLISTIN
  • CAS No.1066-17-7
  • Chemical Name:COLISTIN
  • CBNumber:CB0169873
  • Molecular Formula:C52H98N16O13
  • Formula Weight:1155.43
  • MOL File:1066-17-7.mol
COLISTIN Property
  • Boiling point: :807.67°C (rough estimate)
  • Density  :1.1050 (rough estimate)
  • refractive index  :1.6700 (estimate)
  • CAS DataBase Reference :1066-17-7
  • EWG's Food Scores :1
  • FDA UNII :Z67X93HJG1
  • NCI Drug Dictionary :Coly-Mycin
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements
COLISTIN Price More Price(4)
  • Brand: Sigma-Aldrich
  • Product number: Y0001999
  • Product name : Colistin for system suitability
  • Purity:  European Pharmacopoeia (EP) Reference Standard
  • Packaging: y0001999
  • Price: $128.9
  • Updated: 2020/08/18
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: Y0001999
  • Product name : Colistin for system suitability
  • Purity: European Pharmacopoeia (EP) Reference Standard
  • Packaging: 
  • Price: $128.9
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Cayman Chemical
  • Product number: 23487
  • Product name : Colistin
  • Purity: ≥95%
  • Packaging: 100mg
  • Price: $285
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Cayman Chemical
  • Product number: 23487
  • Product name : Colistin
  • Purity: ≥95%
  • Packaging: 25mg
  • Price: $89
  • Updated: 2021/03/22
  • Buy: Buy

COLISTIN Chemical Properties,Usage,Production

  • Neurotoxicity and Nephrotoxicity Colistin is an antibiotic which is being used more commonly now than when it was introduced because of its activity against multiresistant Gram-negative bacteria, especially Acinetobacter baumanii and Enterobacteriaceae producing extended spectrum β-lactamases. It had a bad reputation due to reports of neurotoxicity and nephrotoxicity. Recent studies have shown lower rates of nephrotoxicity than previously reported. However, in one of these reports, 7/42 patients with high serum creatinine values prior to colistin treatment developed renal failure.
  • Uses Polymyxin E (colistin) is a complex of closely related cyclic peptides E1 and E2, with additional minor analogues. Polymyxin E is produced by Bacillus polymyxa var. colistinus, and is a highly basic, atypical cyclic peptide which incorporates the unusual amino acid, diaminobutyric acid. Head-to-tail coupling of lysine completes the macrocycle. Balancing the polar cyclic peptide is a hydrophobic tail with short chain fatty acids. Polymyxin E is a broad spectrum antibiotic active against Gram negative bacteria. The mechanism of action involves disruption of the bacterial outer membrane by a detergent-like effect.
  • brand name Coly-Mycin (Monarch).
COLISTIN Preparation Products And Raw materials
Raw materials
Preparation Products
Global(62)Suppliers
  • Supplier:
    BOC Sciences
  • Tel:1-631-485-4226
  • Fax:1-631-614-7828
  • Email:inquiry@bocsci.com
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  • Supplier:
    career henan chemical co
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  • Fax:0086-371-86658258
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  • Country:CHINA
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  • Supplier:
    Shaanxi Dideu Medichem Co. Ltd
  • Tel:18192503167 +86-29-89586680
  • Fax:+86-29-88380327
  • Email:1005@dideu.com
  • Country:CHINA
  • ProdList:9937
  • Advantage:58
1066-17-7, COLISTINRelated Search:
  • COLISTIN
  • colimycin
  • 1264-72-8 (Sulfate)
  • Aids033059
  • Aids-033059
  • Colistin, ColiMycin M, BelcoMycin, ColyMycin, Torazin
  • PolyMyxin E coMplex
  • [(2S)-4-amino-1-[[(2S,3R)-1-[[(2S)-4-amino-1-oxo-1-[[(1S,4S,7R,10S,13S,16S,19S)-4,13,16-tris(2-aminoethyl)-19-[(1R)-1-hydroxyethyl]-10-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-7-(phenylmethyl)-3,6
  • Polymyxin E1 sulfate
  • Polyoxin W.P.
  • colisticina
  • colomycin
  • coly-mycin
  • colymysins
  • kangdisu
  • kolimitsin
  • totazina
  • Colistin for system suitability
  • COLISTIN USP/EP/BP
  • 1066-17-7
  • C58H90N16O8