Varespladib sodium treatment inhibits human sPLA2-induced release of thromboxane A2 (TXA2) from isolated guinea pig lung bronchoalveolar lavage cells with an IC50 of 0.79 μM. And the ED50 for Varespladib sodium is 16.1 mg/kg[1].
| Animal Model: | Male Hartley guinea pigs (300-500 g)[1] |
| Dosage: | 3 mg/kg, 10 mg/kg, and 30 mg/kg |
| Administration: | Intravenous injection (Pharmacokinetic study) |
| Result: | Consistent inhibition of sPLA2 activity in BAL fluid was observed. Reduced the human sPLA2-induced generation of TXA2 on BAL cells from guinea pigs. |
![Natrium[(1-benzyl-2-ethyl-3-oxamoylindool-4-yl)oxy]acetaat Structure](https://www.chemicalbook.com/CAS/20150408/GIF/172733-42-5.gif)