Chemical Properties
White crystalline powder, soluble in methanol, derived from the plant Peucedanum purpurogenum and Angelica radix.
Uses
Nodakenin is a compound used for inhibiting influenza virus including Nodakenin and/or Nodakenetin.
Definition
ChEBI: Nodakenin is a furanocoumarin.
Synthesis
1. Rhizome of Qianghuo is extracted with ethanol, concentrated, and acid-hydrolyzed. The hydrolysate is passed through macroporous resin. Elution with ethanol of varying concentrations yields an extract rich in the target.
2. The extract is mixed with silica gel and subjected to silica column chromatography with a petroleum ether-ethyl acetate gradient. The 10:1 fraction is collected and purified by preparative HPLC to obtain nodakenin.
in vivo
Nodakenin (10 mg/kg, p.o.) reverses scopolamine-induced cognitive impairments in the passive avoidance test and the Y-maze test[1].
Nodakenin (10 mg/kg, p.o.) reduces escape latency during training in the Morris water maze test[1].
| Animal Model: | Male ICR mice
|
| Dosage: | 2.5, 5, 10 and 20 mg/kg
|
| Administration: | p.o, single dose
|
| Result: | Reversed in step-through latency induced by scopolamine. |
