Uses
Decursinol angelate, a cytotoxic and protein kinase C (PKC) activating agent from the root of Angelica gigas, possesses anti-tumor and anti-inflammatory activities[1][2].
Biological Activity
Decursinol Angelate is a pyranocoumarin isolated from medical plant Angelica gigas th at exhibits potent anti-inflammatory properties. Decursinol Angelate appears to suppress type 17 helper T (Th17) cell responses in dextran sodium sulfate-induced colitis model. Decursinol Angelate reduces the production of NF-KB and COX-2 induced proinflammatory cytokine levels on TPA induced mice ear edema.
References
[1] Ahn KS, et al. Decursinol angelate: a cytotoxic and protein kinase C activating agent from the root of Angelica gigas. Planta Med. 1997 Aug;63(4):360-1. DOI:
10.1055/s-2006-957701[2] Lee S, et al. Anti-tumor activities of decursinol angelate and decursin from Angelica gigas. Arch Pharm Res. 2003 Sep;26(9):727-30. DOI:
10.1007/BF02976682
