5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine

Uses

It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.

Synthesis

4-chloro-7H-pyrrolo[2,3-d]pyrimidine (30 g/0.02 mol) was dissolved in 75 mL of chloroform, followed by added 3.5 g (0.02 mol) of N-bromosuccinamide. The resulting mixture was refluxed for 1 h. After cooling to room temperature, the precipitate was removed by filtration and dried under reduced pressure to afford 5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine.

References

[1] Organic Letters, 2003, vol. 5, # 20, p. 3587 - 3590
[2] Synthesis, 2011, # 9, p. 1442 - 1446
[3] Archiv der Pharmazie, 2016, vol. 349, # 5, p. 356 - 362
[4] European Journal of Medicinal Chemistry, 2017, vol. 138, p. 543 - 551
[5] Patent: CN107556318, 2018, A. Location in patent: Paragraph 0101-0103; 0106; 0107