Uses
Treatment of
osteoporosis, as an antiosteoporotic, in the treatment of
bone and mineral disease and disorders, bone metabolism
regulator, blood calcium regulator, and as a diagnostic aid
(pseudohypoparathyroidism; hypocalcemia).
Uses
PTH / arathyroid hormone EIA kit has been used to determine parathyroid hormone (PTH) levels in human embryonic kidney (HEK293) cells.
brand name
Paroidin (Parke-Davis).
General Description
The PTH Enzyme Immunoassay (EIA) Kit is an in vitro quantitative assay for detecting PTH peptide based on the principle of Competitive Enzyme Immunoassay.
Biochem/physiol Actions
Parathyroid hormone (PTH) plays a vital role in regulation calcium homeostasis. It increases bone mass in animals and humans by inhibiting osteoblast apoptosis. PTH has potential applications in preventing fractures in postmenopausal women with osteoporosis. Irregular diurnal patterns of PTH leads to sustained mild hypercalcemia in non dialyzed chronic kidney disease (CKD) patients. PTH, along with other heart failure biomarkers play a vital role in measuring disease severity and prognosis of heart failure with preserved ejection fraction (HFpEF). Variation in PTH leads to osteoporosis in asymptomatic hyperparathyroidism (HPT).
Safety Profile
Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating vapors.
