Acrisorcin

acrisorcin Chemische Eigenschaften,Einsatz,Produktion Methoden

• Originator

  Aminacrine hexylresorcinate ,ZYF Pharm

• Verwenden

  Antifungal.

• Manufacturing Process

  4-Hexylresorcinol 194.0 g is added to a solution composed of 56.1 g potassium hydroxide in 1.5 L of water with stirring, and the mixture heated to about 40°C to effect complete solution. The pH of this solution is 12. A second solution of 9-aminoacridine hydrochloride is prepared as follows: 2 L of water containing 83 ml of concentrated hydrochloric acid are heated with stirring to about 80°C. Slowly 194.0 g of 9-aminoacridine are added. Heating is continued until a clear solution is obtained. About 2 ml of additional concentrated hydrochloric acid are added in small increments until the solution is slightly acid (pH of about 6). The 4-hexyl resorcinol solution is now slowly added under rapid agitation to the 9-aminoacridine hydrochloride solution. A copious precipitate is formed which, upon :stirring and continued addition of the 4-hexylresorcinol solution, becomes a creamy yellow slurry. At the end of the addition, the pH is 7-8 (indicator paper). The slurry is stirred while heated for an additional 15 min and then rapidly filtered on a 15 cm Buchner funnel. The product thus obtained is washed thoroughly, using about 1 L of cold water, to give a very pale yellow color in the last wash. The compound is then pressed dry and then oven-dried for 2-3 h at 50°C. The resultant product, 9- aminoacridine 4-hexyl resorcinolate, has a melting point of 189°-190°C.

• Trademarks

  Akrinol (Schering).

• Therapeutic Function

  Antifungal, Anthelmintic

acrisorcin Upstream-Materialien And Downstream Produkte

Acrisorcin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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