Esomeprazole magnesium trihydrate Struktur

Esomeprazole magnesium trihydrate

Bezeichnung:Esomeprazole magnesium trihydrate

CAS-Nr217087-09-7

Englisch Name:Esomeprazole magnesium trihydrate

CBNumberCB9740619

SummenformelC34H38MgN6O7S2

Molgewicht731.14

MOL-Datei217087-09-7.mol

Esomeprazole magnesium trihydrate physikalisch-chemischer Eigenschaften

Schmelzpunkt	184-189°C (dec.)
storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
Löslichkeit	Slightly soluble in water, soluble in methanol, practically insoluble in heptane.
Aggregatzustand	Solid
Farbe	White to off-white
InChI	InChI=1S/2C17H18N3O3S.Mg.H2O/c21-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17;;/h25-8H,9H2,1-4H3;;1H2/q2*-1;+2;
InChIKey	VEVZQDGATGBLIC-UHFFFAOYSA-N
SMILES	C(C1N=CC(C)=C(OC)C=1C)S1C2[N-]C3=CC(OC)=CC=C3N=2[Mg+2]2(O=S(CC3N=CC(C)=C(OC)C=3C)C3[N-]C4=CC(OC)=CC=C4N2=3)O=1.O
CAS Datenbank	217087-09-7(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22
WGK Germany	3
HS Code	2933399090

Gefahreninformationscode (GHS)

Esomeprazole magnesium trihydrate Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften
Off-White Powder
Verwenden
esomeprazole magnesium trihydrate for the healing of peptic ulcers associated with non-steroidal anti-inflammatory drug NSAID (non-selective and COX-2 selective) therapy.
1. Zollinger-Ellison syndrome
2. Peptic ulcer, site unspecified
3. Duodenal ulcer
4. Gastric ulcer
5. Gastro-oesophageal reflux disease
Esomeprazole belongs to the family of medications known as proton pump inhibitors (PPIs). Esomeprazole is registered by the Therapeutic Goods Administration (TGA) for the following indications:
1. Gastro-Oesophageal Reflux Disease (GORD):
2. treatment of erosive reflux oesophagitis;
3. long-term management of patients with healed oesophagitis to prevent relapse;
4. symptomatic treatment of gastro-oesophageal reflux disease (GORD).
In combination with appropriate antibiotics for:
1. healing of duodenal ulcer associated with Helicobacter pylori;
2. eradication of Helicobacter pylori in patients with active or healed peptic ulcer.
3. Short-term treatment of upper gastrointestinal symptoms associated with non-steroidal anti-inflammatory drug (NSAID) (non-selective and COX-2 selective) therapy.
4. Healing of gastric ulcers associated with non-steroidal anti-inflammatory drug NSAID (non-selective and COX-2 selective) therapy.
5. Prevention of gastric and duodenal ulcers associated with non-steroidal anti-inflammatory drug NSAID (non-selective and COX-2 selective) therapy in patients at risk.
Verwenden
S-Form of Omeprazole. Gastric proton-pump inhibitor
Verwenden
Esomeprazole Magnesium Trihydrate is used in preparation of esomeprazole magnesium trihydrate.
Trademarks
Nexium (AstraZeneca).
Biologische Aktivität
Esomeprazole magnesium trihydrate ((S)-Omeprazole magnesium trihydrate) is a potent, orally active H+, K+-ATPase inhibitor. Esomeprazole magnesium trihydrate has the potential for upper intestinal disorders and gastroesophageal reflux disease research. Esomeprazole magnesium trihydrate acts as an exosome inhibitor by blocking the exosome release by inhibiting V-H+-ATPases.

Esomeprazole magnesium trihydrate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

217087-09-7, Esomeprazole magnesium trihydrate Verwandte Suche:

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