Thiamine disulfide Struktur

N,N'-[Dithiobis[2-(2-hydroxyethyl)-1-methylvinylen]]bis[N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]formamid

Bezeichnung:N,N'-[Dithiobis[2-(2-hydroxyethyl)-1-methylvinylen]]bis[N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]formamid

CAS-Nr67-16-3

Englisch Name:Thiamine disulfide

CBNumberCB9722783

SummenformelC24H34N8O4S2

Molgewicht562.71

MOL-Datei67-16-3.mol

Synonyma

N,N'-[Dithiobis[2-(2-hydroxyethyl)-1-methylvinylen]]bis[N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]formamid

N,N'-[Dithiobis[2-(2-hydroxyethyl)-1-methylvinylen]]bis[N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]formamid physikalisch-chemischer Eigenschaften

Schmelzpunkt	177° with intense yellow coloration
Siedepunkt	886.1±65.0 °C(Predicted)
Dichte	1.1966 (rough estimate)
Brechungsindex	1.7400 (estimate)
storage temp.	Refrigerator
Löslichkeit	DMSO (Slightly), Methanol (Slightly)
Aggregatzustand	Solid
pka	14.10±0.10(Predicted)
Farbe	White
Merck	14,9297
CAS Datenbank	67-16-3(CAS DataBase Reference)
EPA chemische Informationen	Formamide, N,N'-[dithiobis[2-(2-hydroxyethyl)-1-methyl-2,1-ethenediyl]]bis[N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]- (67-16-3)

Sicherheit

RTECS-Nr.	LQ2715000
HS Code	2936.22.0000
Toxizität	LD50 intravenous in mouse: 500mg/kg

Gefahreninformationscode (GHS)

Thiamine disulfide Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften
White Solid
Originator
Arcalion,Servier,France,1974
Verwenden
Thiamine is a essential nutrient required for carbohydrate metabolism; also involved in nerve function. Biosynthesized by microorganisms and plants. Dietary sources include whole grains, meat products , vegetables, milk, legumes and fruit. Also present in rice husks and yeast. Converted in vivo to Thiamine diphosphate, a coenzyme in the decarboxylation of α-keto acids. Chronic deficiency may lead t o neurological impairment, bariberi, Wernicke-Korsakoff syndrome.
Verwenden
Thiamine disulfide is an antioxidant, inhibiting lipid peroxidation in rat liver microsomes and free radical oxidation of oleic acid in vitro. Thiamine disulfide has been explored as a potent inhibitor of HIV-1.
Definition
ChEBI: Thiamine disulfide is an aminopyrimidine, a homoallylic alcohol, a member of formamides and an organic disulfide.
Manufacturing Process
20 parts by weight of thiamin are dissolved in 25 parts of water, a cold solution of 5 parts by weight of caustic soda in 25 parts of water added and the mixture oxidized with a solution of 2.4 parts by weight of caustic soda and 20 parts by weight of potassium ferric cyanide in 80 parts of water while stirring in the cold. The liquid is then evaporated to dryness and the resulting oxidation product extracted with warm butyl alcohol.
The butyl-alcoholic solution is evaporated in vacuo and the residue dissolved with gentle heating in 25 parts by volume of methyl alcohol. 100 parts by volume of acetone are added, the solution filtered and further quantities of acetone added, whereupon crystallization sets in. Yield: 12.2 parts by weight of the pure product, having the melting point 177° to 179°C.
Therapeutic Function
Enzyme cofactor vitamin

Thiamine disulfide Upstream-Materialien And Downstream Produkte

N,N'-[Dithiobis[2-(2-hydroxyethyl)-1-methylvinylen]]bis[N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]formamid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

67-16-3, Thiamine disulfide Verwandte Suche:

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