Thiram

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H315：Verursacht Hautreizungen.

  H317：Kann allergische Hautreaktionen verursachen.

  H319：Verursacht schwere Augenreizung.

  H373：Kann die Organe schädigen bei längerer oder wiederholter Exposition.

  H410：Sehr giftig für Wasserorganismen mit langfristiger Wirkung.

• Sicherheit

  P273：Freisetzung in die Umwelt vermeiden.

  P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

  P301+P312：BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

  P302+P352：BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.

  P314：Bei Unwohlsein ärztlichen Rat einholen / ärztliche Hilfe hinzuziehen.

Tetramethylthiuram Disulfide Chemische Eigenschaften,Einsatz,Produktion Methoden

• ERSCHEINUNGSBILD

  FARBLOSE KRISTALLE.

• PHYSIKALISCHE GEFAHREN

  Staubexplosion der pulverisierten oder granulierten Substanz in Gemischen mit Luft möglich.

• CHEMISCHE GEFAHREN

  Zersetzung beim Verbrennen, unter Bildung giftiger Rauche mit Schwefeloxiden und Kohlenstoffsulfid. Reagiert mit starken Oxidationsmitteln, Säuren und oxidierbaren Stoffen.

• ARBEITSPLATZGRENZWERTE

  TLV: 1 mg/m?(als TWA); Krebskategorie A4 (nicht klassifizierbar als krebserzeugend für den Menschen); (ACGIH 2005).
  MAK: 1 mg/m?(Einatembare Fraktion); Spitzenbegrenzung: überschreitungsfaktor II(2); Sensibilisierung der Haut; Schwangerschaft: Gruppe C; (DFG 2006).
  

• AUFNAHMEWEGE

  Aufnahme in den Körper durch Inhalation des Aerosols und durch Verschlucken.

• INHALATIONSGEFAHREN

  Verdampfung bei 20°C vernachlässigbar; eine gesundheitsschädliche Partikelkonzentration in der Luft kann jedoch beim Versprühen oder Dispergieren schnell erreicht werden, vor allem als Pulver.

• WIRKUNGEN BEI KURZZEITEXPOSITION

  WIRKUNGEN BEI KURZZEITEXPOSITION:
  Die Substanz reizt die Augen, die Haut und die Atemwege.

• WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION

  Wiederholter oder andauernder Kontakt kann zu Hautsensibilisierung führen. Möglich sind Auswirkungen auf Schilddrüseund Leber.

• LECKAGE

  Verschüttetes Material in Behältern sammeln; falls erforderlich durch Anfeuchten Staubentwicklung verhindern. Reste sorgfältig sammeln. An sicheren Ort bringen. Chemikalienschutzanzug mit umgebungsluftunabhängigem Atemschutzgerät. NICHT in die Umwelt gelangen lassen.

• R-Sätze Betriebsanweisung:

  R20/22:Gesundheitsschädlich beim Einatmen und Verschlucken.
  R36/38:Reizt die Augen und die Haut.
  R43:Sensibilisierung durch Hautkontakt möglich.
  R48/22:Gesundheitsschädlich: Gefahr ernster Gesundheitsschäden bei längerer Exposition durch Verschlucken.
  R50/53:Sehr giftig für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.

• S-Sätze Betriebsanweisung:

  S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
  S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
  S60:Dieses Produkt und sein Behälter sind als gefährlicher Abfall zu entsorgen.
  S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.

• Beschreibung

  Tetramethylthiuram disulfide is a rubber chemieal, an accelerator of vulcanization. It represents the most commonly positive allergen contained in the "thiuram mix". The most frequent occupational categories are the metal industry, homemakers, health services and laboratories, building industries, and shoemakers.

• Chemische Eigenschaften

  Thiram is a colorless to yellow, crystalline solid. Characteristic odor. Commercial pesticide products may be dyed blue.

• Chemische Eigenschaften

  white to almost white powder

• Physikalische Eigenschaften

  Colorless to white to cream-colored crystals. May darken on exposure to air or light.

• Verwenden

  Tetramethylthiuram disulfide is used as fungicide; bacteriostat; pesticide; rubber vulcanization accelerator; scabicide; seed disinfectant; animal repellent; insecticide; lube-oil additive; wood preservative; in antiseptic sprays; in the blending of lubrieant oils; used against Botrytis, rusts and downy mildews; seed dressing against "damping off' and verticillium wilt; ethanol antagonist and deterrent in mixtures of the methyl, ethyl, propyl, and butyl derivatives; antioxidant in polyolefin plastics; peptizing agent in polysulphide elastomers; in soaps and rodent repellents; nut, fruit, and mushroom disinfectant.

• Verwenden

  Thiram is a protective fungicide applied to foliage to control Botrytis spp. on grapes, soft fruit, lettuce, vegetables and ornamentals. It also controls rust on ornamentals, scab and storage diseases on apple and pear and leaf curl and Monilia on stone fruit. It is used in seed treatments alone or in combination with added insecticides or fungicides to control damping off diseases such as Pythium spp., and other diseases like Fusarium spp. of maize, cotton, cereals, legumes, vegetables and ornamentals.

• Verwenden

  antianginal

• Verwenden

  Thiram is an ectoparasiticide. Thiram is used in agriculture to prevent fungal diseases in seed and crops. Thiram has other applications ranging from use as a topical bactericide to animal repellent.

• Verwenden

  Rubber accelerator; vulcanizer; seed disinfectant; fungicide; bacteriostat in soap; animal repellent.

• Definition

  ChEBI: An organic disulfide that results from the formal oxidative dimerisation of N,N-dimethyldithiocarbamic acid. It is widely used as a fungicidal seed treatment.

• Allgemeine Beschreibung

  A liquid solution of a white crystalline solid. Primary hazard is to the environment. Immediate steps should be taken to limit spread to the environment. Easily penetrates the soil to contaminates groundwater and waterways.

• Air & Water Reaktionen

  Insoluble in water. Decomposes in acidic media to give toxic products. Decomposes to an extent on prolonged exposure to heat, air or moisture.

• Reaktivität anzeigen

  TMTD is incompatible with oxidizing materials and strong acids. Also incompatible with strong alkalis and nitrating agents .

• Hazard

  Toxic by ingestion and inhalation, irritant to skin and eyes. Body weight and hematologic effects. Questionable carcinogen.

• Health Hazard

  Inhalation of dust may cause respiratory irritation. Liquid irritates eyes and skin and may cause allergic eczema in sensitive individuals. Ingestion causes nausea, vomiting, and diarrhea, all of which may be persistent; paralysis may develop.

• Brandgefahr

  Special Hazards of Combustion Products: Toxic and irritating oxides of sulfur are formed. Carbon disulfide may be formed from unburned material.

• Landwirtschaftliche Anwendung

  Fungicide, Rodenticide: Thiram is used as a fungicide to prevent crop damage in the field and to prevent crops from deterioration in storage or transport. Thiram is also used as a seed, nut, fruit, and mushroom disinfectant from a variety of fungal diseases. In addition, it is used as an animal repellent to protect fruit trees and ornamentals from damage by rabbits, rodents, and deer. Thiram has been used in the treatment of human scabies, as a sun screen, and as a bactericide applied directly to the skin or incorporated into soap. Thiram is used as a rubber accelerator and vulcanizer and as a bacteriostat for edible oils and fats. It is also used as a rodent repellent, wood preservative, and may be used in the blending of lubricant oils. Registered for use in EU countries. Registered for use in the U.S.

• Handelsname

  AAPIROL®; AATACK®; AATIRAM®; ACCELERATOR T®; ACCELERATOR THIURAM®; ACCEL TMT®; AGROSOL POUR-ON®; ANLES®; ARASAN®[C]; ATIRAM®; ATTACK®; AULES®; CHIPCO THIRAM 75®; CRYLCOAT®; CUNITEX®; CYURAM DS®; DELSAN®; EBECRYL®; EKAGOM TB®; EVERSHIELD T SEED PROTECTORANT®; FALITIRAM®; FERMIDE®; FERNACOL®; FERNASAN®; FERNIDE®; FLO PRO T SEED PROTECTANT®; FMC 2070®[C]; FORMALSOL®; HERMAL®; HERYL®; HEXATHIR®; HY-VIC®; KODIAK T®; KREGASAN®; LIQUID MOLY-CO-THI®; MERCURAM®; METIURAC®; MOLY-T®; NA2771®; NOBECUTAN®; NOMERSAN®; NORMERSAN®; OPTIMA®; PANORAM 75®; POLYRAM ULTRA®; POMARSOL®; POMARSOL FORTE®; POMASOL®; PRO-GRO®; PURALIN®; RAXIL®; REZIFILM®; ROOTONE®; ROYAL TMTD®; RTUBAYTAN- THIRAM®; RTU FLOWABLE SOYBEAN FUNGICIDE®; SADOPLON®; SOLUCRYL®; SPOTRETE®; SPOTRETE-F®; SQ 1489®; SRANANSF- X®; TERSAN 75®[C]; TERSANTETRAMETHYL DIURANE SULFIDE®; TETRAPOM®; TETRASIPTON®; THIANOSAN®; THILLATE®; THIMAR®; THIMER®; THIOKNOCK®; THIOSAN®; THIOSCABIN®; THIOTEX®; THIOTOX®; THIRAM 75®; THIRAM 80®; THIRAMAD®; THIRAM B®; THIRAMPA®; THIRASAN®; THIULIN®; THIULIX®; THIURAD®; THIURAMIN®; THIURAMYL®; THYLATE®; TIRAMPA®; TITAN FL®; TRAMETAN®; TRIDIPAM®; TRIPOMOL®; TUADS®; TUEX®; TULISAN®; UCECOAT®; UCECRYL®; UVECRYL®; VANCIDA TM-95®; VANCIDE TM®; VITAFLO 280®; VITAVAX® Thiram; VITAVAX-T®; VUAGT-1-4®; VULCAFOR TMTD®; VULKACIT MTIC®; VULKACIT THIURAM®; VULKACIT THIURAM/C®

• Kontakt-Allergie

  TITD is a rubber vulcanization accelerator

• Kontakt-Allergie

  This rubber chemical, accelerator of vulcanization, represents the most commonly positive allergen contained in “thiuram mix.” The most frequent occupational categories are the metal industry, homemakers, health services and laboratories, the building industry, and shoemakers. It is also widely used as a fungicide, belonging to the dithiocarbamate group of carrots, bulbs, and woods, and as an insecticide. Thiram is the agricultural name for thiuram.

• Sicherheitsprofil

  Poison by ingestion and intraperitoneal routes. Questionable carcinogen with experimental tumorigenic and teratogenic data. Other experimental reproductive effects. Mutation data reported, Affects human pulmonary system. A rmld allergen and irritant. Acute poisoning in experimental animals produced liver, hdney, and brain damage. Dangerous in a fire; see NITROGEN MONOXIDE and SULFUR DIOXIDE.

• mögliche Exposition

  Thiram is a dithiocarbamate. Some thiurams have been used as rubber components: thiram is used as a rubber accelerator and vulcanizer; a seed, nut, fruit, and mushroom disinfectant; a bacteriostat for edible oils and fats; and as an ingredient in suntan and antiseptic sprays and soaps. It is also used as a fungicide, rodent repellent; wood preservative; and may be used in the blending of lubricant oils.

• Carcinogenicity

  Thiram also was not carcinogenic in rats by gavage or in mice by single subcutaneous injection. In skin painting studies in mice thiram had tumor-initiating and -promoting activity but was not a complete carcinogen.
  Thiram was genotoxic to insects, plants, fungi, and bacteria: it induced sister chromatid exchange and unscheduled DNA synthesis in cultured human cells. Despite established genotoxicity in vitro, it showed no clastogenic and/or aneugenic activity in vivo after oral administration to mice at the maximum tolerated dose.

• Environmental Fate

  Biological. In both soils and water, chemical and biological mediated reactions can transform thiram to compounds containing the mercaptan group (Alexander, 1981). Odeyemi and Alexander (1977) isolated three strains of Rhizobium sp. that degraded thiram. One of these strains, Rhizobium meliloti, metabolized thiram to yield dimethy- lamine (DMA) and carbon disul?de which formed spontaneously from dimethyldithiocar- bamate (DMDT). The conversion of DMDT to DMA and carbon disul?de occurred via enzymatic and nonenzymatic mechanisms (Odeyemi and Alexander, 1977).
  When thiram (100 ppm) was inoculated with activated sludge (30 ppm) at 25°C and pH 7.0 for two weeks, 30% degraded. Metabolites included methionine, elemental sulfur, formaldehyde, dimethyldithiocarbamate-α-aminobutyric acid and the corresponding keto aci
  To a non-autoclaved alluvial sandy loam (pH 7.3) fortified and inoculated with the bacterium Pseudomonas aeruginosa, 40 and 86% degradation were observed after 4 and 24 days, respectively. In autoclaved soil, thiram degradation was not affected. Degradat
  Soil. Decomposes in soils to carbon disul?de and dimethylamine (Sisler and Cox, 1954; Kaars Sijpesteijn et al., 1977). When a spodosol (pH 3.8) pretreated with thiram was incubated for 24 days at 30°C and relative humidity of 60–90%, dimethylamine formed as the major product. Minor degradative products included nitrite ions (nitration reduction) and dimethylnitrosamine (Ayanaba et al., 1973).
  Plant. Major plant metabolites are ethylene thiourea, thiram monosul?de, ethylene thiram disul?de and sulfur (Hartley and Kidd, 1987).

• Stoffwechselwegen

  Dialkyldithiocarbamates chelate copper and inhibit pyruvate dehydrogenase. It is likely that the mode of action of chelators is principally through their effect on lipoamide containing dehydrogenases (Corbett et al., 1984). Thiram generates dimethyldithiocarbamic acid by being cleaved in acidic conditions and in biological media. The acid is conjugated with glucose and alanine in plants and with glucuronic acid in mammals. Dimethyldithiocarbamic acid is further degraded to dimethylamine and CS2. An extensive review of the properties of dithiocarbamate pesticides was published by the World Health Organisation (WHO, 1988) from which much of the following information is taken.

• Versand/Shipping

  UN2771 Thiocarbamate pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

• läuterung methode

  Crystallise thiram (three times) from boiling CHCl3, then recrystallise it from boiling CHCl3 by adding EtOH dropwise to initiate crystallisation, and allow it to cool. Finally it is precipitated from cold CHCl3 by adding EtOH (which retains the monosulfide in solution). [Ferington & Tobolsky J Am Chem Soc 77 4510 1955, Beilstein 4 IV 242.]

• Degradation

  Thiram is decomposed in acidic media. It deteriorates on prolonged exposure to heat, air or moisture. DT₅₀ values are estimated as 128 days, 18 days and 9 hours at pH 4, 7 and 9, respectively (PM). The dimethyldithiocarbamate (2) is stable in alkaline media but unstable in acidic conditions, decomposing to dimethylamine and carbon disulfide. In water, the dimethyldithiocarbamate can be oxidatively degraded to a number of products. The rate of degradation depends on pH and the type of any cations that might be present. The rate of decomposition and production of CS2 is decreased by cations in the following order Na+ > Zn2+> Fe3+> Cu2+. Thiram was completely degraded in sewage water in 12 days.
  An ethanolic solution of unlabelled thiram (4 g l^-1) was exposed to UV light for 48 hours. The reaction tube was encircled by low pressure Hg lamps that gave more than 85% of their total radiation at 253.7 nm. Pure nitrogen was bubbled through the solutions. Photo-oxidation studies were done similarly except that oxygen was bubbled through the solution. In further experiments, irradiation was by visible light from a tungsten lamp and again oxygen was bubbled through the solution. The outlet gases from the UV study were condensed in a cold trap and analysed by GC-MS. Traces of carbon disulfide and dimethylamine were identified. The reaction mixture was also analysed by GC-MS and three products were identified as tetramethyl hydrazine (3), N,N-dimethylthioformamide (4) and tetramethylthiourea (5). The identity of the latter was confirmed by IR and NMR. The reaction mixture was concentrated and applied to TLC plates and sulfur and tetramethylthiourea (5) were identified as the main products of photolysis. The same products with the addition of sulfur dioxide and carbon dioxide were produced by UV light and oxygen. Oxidation of thiram in the presence of visible light together with Rose Bengal as a photosensitiser also gave the same products in almost identical yields. The results confirm that C-S and S-S bond fissions are primary photochemical steps with dithiocarbamates.

• Toxicity evaluation

  Thiram cytotoxicity appears to result from its potential to disrupt cellular defense mechanisms against oxidative stress. In cultured human skin fibroblast, thiram results in an increase in oxidative markers such as lipid peroxidation and oxidation of reduced glutathione and decrease in other endogenous antioxidant. Toxic effects of thiram have been described in humans and animal model systems ranging from liver injury, testicular toxicity, ophthalmological changes, and development of micronuclei in bone marrow. However, the mechanisms of these effects are not characterized and inconsistent across various studies.

• Inkompatibilitäten

  Dust may form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine,fluorine, etc.); contact may cause fires or explosions. Keep away from strong alkaline materials, strong acids, strong bases and nitrating agents.

• Waste disposal

  Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. Thiram can be dissolved in alcohol or other flammable solvent and burned in an incinerator with an afterburner and scrubber.

Tetramethylthiuram Disulfide Upstream-Materialien And Downstream Produkte

Thiram Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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