Brotizolam

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H336：Kann Schläfrigkeit und Benommenheit verursachen.

  H361：Kann vermutlich die Fruchtbarkeit beeinträchtigen oder das Kind im Mutterleib schädigen.

  H362：Kann Säuglinge über die Muttermilch schädigen.

• Sicherheit

  P201：Vor Gebrauch besondere Anweisungen einholen.

  P202：Vor Gebrauch alle Sicherheitshinweise lesen und verstehen.

  P260：Dampf/Aerosol/Nebel nicht einatmen.

  P261：Einatmen von Staub vermeiden.

  P263：Kontakt während der Schwangerschaft /und der Stillzeit vermeiden.

  P264：Nach Gebrauch gründlich waschen.

  P264：Nach Gebrauch gründlich waschen.

  P270：Bei Gebrauch nicht essen, trinken oder rauchen.

  P271：Nur im Freien oder in gut belüfteten Räumen verwenden.

  P281：Vorgeschriebene persönliche Schutzausrüstung verwenden.

  P304+P340：BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen.

  P308+P313：BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.

  P312：Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

  P403+P233：An einem gut belüfteten Ort aufbewahren. Behälter dicht verschlossen halten.

  P405：Unter Verschluss aufbewahren.

  P501：Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

BROTIZOLAM Chemische Eigenschaften,Einsatz,Produktion Methoden

• Beschreibung

  Brotizolam is a hypnotic/sedative approximately 60-100 times more potent than flurazepam. As with other short-acting, annulated benzodiazepines (e.g., triazolam), cited advantages include lack of adverse effects on sleep and performance after arousal.

• Chemische Eigenschaften

  Tan Solid

• Originator

  Boehringer Ingelheim (W. Germany)

• Verwenden

  A hypnotic and a sedative, also used in veterinary medicine as an appetite stimulant

• Definition

  ChEBI: Brotizolam is an organic molecular entity.

• Manufacturing Process

  (a) 11.5 g of 7-bromo-5-(o-chlorophenyl)-3H-[2,3e]-thieno-1,4-diazepin-2- one (see German Patent 2,221,623), were heated at 55° to 60°C with 100 cc of absolute pyridine and 6.5 g of phosphorus pentasulfide for 4 hours while stirring. The mixture was allowed to cool and was then poured into 100 cc of saturated ice-cold NaCl solution. The precipitate was collected by suction filtration, washed with water, dissolved in 100 cc of methylene chloride, the solution was dried and evaporated, and the residue was treated with a little methylene chloride. After suction filtration, 6 g of brown crystalline 7-bromo- 5-(o-chlorophenyl)-3H-[2,3e]-thieno-1,4-diazepine-2-thione, melting point 214°C (decomposition) were obtained.
  (b) 6.0 g of this compound were suspended in 100 cc of tetrahydrofuran, and the suspension was stirred at room temperature with 1.2 g of hydrazine hydrate for 20 minutes. After evaporation to about 10 cc, 20 cc of ether were added, and the crystals were collected by suction filtration. Yield: 5.2 g of 7- bromo-5-(o-chlorophenyl)-2-hydrazino-3H-[2,3e]-thieno-1,4-diazepine, melting point about 300°C (decomposition).
  (c) 5.2 g of this compound were suspended in 50 cc of orthotriethyl acetate, and the suspension was heated to 80°C. After about 30 minutes a clear solution was first formed from which later colorless crystals separated out. The mixture was allowed to cool, and the crystals were collected by suction filtration and washed with ether. Yield: 5 g of the compound, melting point 211° to 213°C.

• Trademarks

  Lendorm (Boehringer Ingelheim);LENDORMIN.

• Therapeutic Function

  Psychotropic

BROTIZOLAM Upstream-Materialien And Downstream Produkte

57801-81-7, BROTIZOLAM Verwandte Suche: